NMDA receptors and long-term potentiation in the hippocampus

Zafar I. Bashir, Nicola Berretta, Zuner A. Bortolotto, Kath Clark, Ceri H. Davies, Bruno G. Frenguelli, Jenni Harvey, Brigitte Potier, Graham L. Collingridge

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

N-methyl-d-aspartate (NMDA) receptors have been shown to have two important physiological roles in the vertebrate central nervous system; they are mediators of synaptic transmission in many pathways in the brain and they are critically involved in neuronal plasticity. This chapter considers long-term potentiation (LTP) in the hippocampus, the first identified and most extensively investigated form of plasticity involving NMDA receptors. The involvement of NMDA receptors in synaptic transmission in the hippocampus is also considered in detail in view of the inextricable link between synaptic transmission and plasticity that NMDA receptors confer upon a synapse.

Original languageEnglish
Title of host publicationThe NMDA Receptor
EditorsG. L. Collingridge, J. C. Watkins
Place of PublicationOxford
PublisherOxford University Press
Chapter13
Pages294-314
Number of pages21
ISBN (Electronic)9780191724701
ISBN (Print)9780192625021
DOIs
Publication statusPublished - 2012

Keywords

  • Central nervous system
  • Hippocampus
  • LTP
  • Neuronal plasticity
  • NMDA receptors
  • Synaptic transmission

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