NMDA receptors and long-term potentiation in the hippocampus

Zafar I. Bashir; Nicola Berretta; Zuner A. Bortolotto; Kath Clark; Ceri H. Davies; Bruno G. Frenguelli; Jenni Harvey; Brigitte Potier; Graham L. Collingridge

doi:10.1093/acprof:oso/9780192625021.003.0013

NMDA receptors and long-term potentiation in the hippocampus

Zafar I. Bashir, Nicola Berretta, Zuner A. Bortolotto, Kath Clark, Ceri H. Davies, Bruno G. Frenguelli, Jenni Harvey, Brigitte Potier, Graham L. Collingridge

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

N-methyl-d-aspartate (NMDA) receptors have been shown to have two important physiological roles in the vertebrate central nervous system; they are mediators of synaptic transmission in many pathways in the brain and they are critically involved in neuronal plasticity. This chapter considers long-term potentiation (LTP) in the hippocampus, the first identified and most extensively investigated form of plasticity involving NMDA receptors. The involvement of NMDA receptors in synaptic transmission in the hippocampus is also considered in detail in view of the inextricable link between synaptic transmission and plasticity that NMDA receptors confer upon a synapse.

Original language	English
Title of host publication	The NMDA Receptor
Editors	G. L. Collingridge, J. C. Watkins
Place of Publication	Oxford
Publisher	Oxford University Press
Chapter	13
Pages	294-314
Number of pages	21
ISBN (Electronic)	9780191724701
ISBN (Print)	9780192625021
DOIs	https://doi.org/10.1093/acprof:oso/9780192625021.003.0013
Publication status	Published - 2012

Keywords

Central nervous system
Hippocampus
LTP
Neuronal plasticity
NMDA receptors
Synaptic transmission

ASJC Scopus subject areas

General Neuroscience

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10.1093/acprof:oso/9780192625021.003.0013

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Bashir, Z. I., Berretta, N., Bortolotto, Z. A., Clark, K., Davies, C. H., Frenguelli, B. G., Harvey, J., Potier, B., & Collingridge, G. L. (2012). NMDA receptors and long-term potentiation in the hippocampus. In G. L. Collingridge, & J. C. Watkins (Eds.), The NMDA Receptor (pp. 294-314). Oxford University Press. https://doi.org/10.1093/acprof:oso/9780192625021.003.0013

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keywords = "Central nervous system, Hippocampus, LTP, Neuronal plasticity, NMDA receptors, Synaptic transmission",

author = "Bashir, {Zafar I.} and Nicola Berretta and Bortolotto, {Zuner A.} and Kath Clark and Davies, {Ceri H.} and Frenguelli, {Bruno G.} and Jenni Harvey and Brigitte Potier and Collingridge, {Graham L.}",

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T1 - NMDA receptors and long-term potentiation in the hippocampus

AU - Bashir, Zafar I.

AU - Berretta, Nicola

AU - Bortolotto, Zuner A.

AU - Clark, Kath

AU - Davies, Ceri H.

AU - Frenguelli, Bruno G.

AU - Harvey, Jenni

AU - Potier, Brigitte

AU - Collingridge, Graham L.

PY - 2012

Y1 - 2012

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AB - N-methyl-d-aspartate (NMDA) receptors have been shown to have two important physiological roles in the vertebrate central nervous system; they are mediators of synaptic transmission in many pathways in the brain and they are critically involved in neuronal plasticity. This chapter considers long-term potentiation (LTP) in the hippocampus, the first identified and most extensively investigated form of plasticity involving NMDA receptors. The involvement of NMDA receptors in synaptic transmission in the hippocampus is also considered in detail in view of the inextricable link between synaptic transmission and plasticity that NMDA receptors confer upon a synapse.

KW - Central nervous system

KW - Hippocampus

KW - LTP

KW - Neuronal plasticity

KW - NMDA receptors

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SN - 9780192625021

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BT - The NMDA Receptor

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PB - Oxford University Press

CY - Oxford

ER -

NMDA receptors and long-term potentiation in the hippocampus

Abstract

Keywords

ASJC Scopus subject areas

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