NMR approaches in structure-based lead discovery: recent developments and new frontiers for targeting multi-protein complexes

Search results

• Finished

  DrugE3CRL's: Probing Druggability of Multisubunit Complexes: E3 Cullin RING Ligases (ERC Starting Grant)

  Ciulli, A. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/05/13 → 30/04/18

  Project: Research

  • Ubiquitin Ligase 100%
  • Proteolysis 86%
  • Small Molecule 57%
  • Ubiquitin-Conjugating Enzyme 54%
  • Ternary Complex 54%

• Dissecting and Exploiting Molecular Recognition at Protein-Protein Interfaces (David Phillips Fellowship)

  Ciulli, A. (Investigator)

  Biotechnology and Biological Sciences Research Council

  8/04/13 → 7/07/15

  Project: Research

  • Small Molecule 100%
  • Bromodomain 90%
  • Ubiquitin-Conjugating Enzyme 78%
  • Ubiquitin Ligase 70%
  • Cullin 51%

• A Systems Approach for the Fragment-based Development of Selective Chemical Probes of Bromodomain Function (joint with University of Oxford)

  Ciulli, A. (Investigator)

  Biotechnology and Biological Sciences Research Council

  8/04/13 → 7/06/15

  Project: Research

  • Bromodomain 100%
  • Small Molecule 60%
  • Proteolysis 48%
  • Bromo 34%
  • BRD4 34%