TY - JOUR
T1 - No Benefit of an Adjunctive Phototherapy Protocol in Treatment of Periodontitis
T2 - A split-mouth randomized controlled trial
AU - Preshaw, Philip M.
AU - Ide, Mark
AU - Bissett, Susan M.
AU - Holliday, Richard
AU - Lansdowne, Nichola
AU - Pickering, Kimberley
AU - Taylor, Judy A.
AU - Levonian, Ana M.
AU - Pleasance, Christine
AU - Guarnelli, Maria Elena
AU - Simonelli, Anna
AU - Fabbri, Chiara
AU - Farina, Roberto
AU - Panagakos, Fotinos S.
AU - Trombelli, Leonardo
N1 - Funding Information:
The authors thank all of the patients who participated in this research. Funding for the study was provided by Colgate‐Palmolive (Europe) via research grants to the host institutions of the lead investigators (P.M. Preshaw, M. Ide, L. Trombelli) at the three study centres (Newcastle University, King’s College London, and University of Ferrara). At the Newcastle centre, the research took place in the Newcastle Dental Clinical Research Facility of the Newcastle University School of Dental Sciences and the Newcastle upon Tyne Hospitals NHS Foundation Trust.
Funding Information:
P.M. Preshaw has received research funding, honoraria and travel grants from Colgate and from Philips Research. M. Ide has received research funding and honoraria from Colgate and from GlaxoSmithKline. L. Trombelli has received honoraria and travel grants from Colgate. F.S. Panagakos was previously an employee of Colgate‐Palmolive.
Publisher Copyright:
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2021/8
Y1 - 2021/8
N2 - Aim: To assess the efficacy of a commercially available adjunctive phototherapy protocol (“Perio-1”) in treatment of periodontitis.Materials and Methods: In an examiner-blind, randomized, controlled, split-mouth, multicentre study, 60 periodontitis patients received root surface debridement (RSD) in sextants either alone (control sextants) or with the adjunctive phototherapy protocol (test sextants). Re-evaluation was performed at 6, 12 and 24 weeks.Results: No statistically significant differences in mean (± standard deviation) clinical attachment level (CAL) change from baseline to week 24 were observed between test (−1.00 ± 1.16 mm) and control sextants (−0.87 ± 0.79 mm) at sites with probing pocket depths (PPDs) ≥5 mm (“deep sites”) at baseline (p =.212). Comparisons between test and control sextants for all other parameters (CAL change at all sites, PPD change at deep sites/all sites, bleeding on probing, plaque scores), and for all change intervals, failed to identify any statistically significant differences.Conclusions: The phototherapy protocol did not provide any additional clinical benefits over those achieved by RSD alone. (German Clinical Trials Register DRKS00011229).
AB - Aim: To assess the efficacy of a commercially available adjunctive phototherapy protocol (“Perio-1”) in treatment of periodontitis.Materials and Methods: In an examiner-blind, randomized, controlled, split-mouth, multicentre study, 60 periodontitis patients received root surface debridement (RSD) in sextants either alone (control sextants) or with the adjunctive phototherapy protocol (test sextants). Re-evaluation was performed at 6, 12 and 24 weeks.Results: No statistically significant differences in mean (± standard deviation) clinical attachment level (CAL) change from baseline to week 24 were observed between test (−1.00 ± 1.16 mm) and control sextants (−0.87 ± 0.79 mm) at sites with probing pocket depths (PPDs) ≥5 mm (“deep sites”) at baseline (p =.212). Comparisons between test and control sextants for all other parameters (CAL change at all sites, PPD change at deep sites/all sites, bleeding on probing, plaque scores), and for all change intervals, failed to identify any statistically significant differences.Conclusions: The phototherapy protocol did not provide any additional clinical benefits over those achieved by RSD alone. (German Clinical Trials Register DRKS00011229).
KW - fluorescence
KW - periodontal debridement
KW - periodontitis
KW - photobiomodulation therapy
KW - phototherapy
KW - randomized controlled trial
UR - http://www.scopus.com/inward/record.url?scp=85105965938&partnerID=8YFLogxK
U2 - 10.1111/jcpe.13465
DO - 10.1111/jcpe.13465
M3 - Article
C2 - 33817809
SN - 0303-6979
VL - 48
SP - 1093
EP - 1102
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
IS - 8
ER -