No Benefit of an Adjunctive Phototherapy Protocol in Treatment of Periodontitis: A split-mouth randomized controlled trial

Philip M. Preshaw (Lead / Corresponding author), Mark Ide, Susan M. Bissett, Richard Holliday, Nichola Lansdowne, Kimberley Pickering, Judy A. Taylor, Ana M. Levonian, Christine Pleasance, Maria Elena Guarnelli, Anna Simonelli, Chiara Fabbri, Roberto Farina, Fotinos S. Panagakos, Leonardo Trombelli

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Aim: To assess the efficacy of a commercially available adjunctive phototherapy protocol (“Perio-1”) in treatment of periodontitis.

    Materials and Methods: In an examiner-blind, randomized, controlled, split-mouth, multicentre study, 60 periodontitis patients received root surface debridement (RSD) in sextants either alone (control sextants) or with the adjunctive phototherapy protocol (test sextants). Re-evaluation was performed at 6, 12 and 24 weeks.

    Results: No statistically significant differences in mean (± standard deviation) clinical attachment level (CAL) change from baseline to week 24 were observed between test (−1.00 ± 1.16 mm) and control sextants (−0.87 ± 0.79 mm) at sites with probing pocket depths (PPDs) ≥5 mm (“deep sites”) at baseline (p =.212). Comparisons between test and control sextants for all other parameters (CAL change at all sites, PPD change at deep sites/all sites, bleeding on probing, plaque scores), and for all change intervals, failed to identify any statistically significant differences.

    Conclusions: The phototherapy protocol did not provide any additional clinical benefits over those achieved by RSD alone. (German Clinical Trials Register DRKS00011229).

    Original languageEnglish
    Pages (from-to)1093-1102
    Number of pages10
    JournalJournal of Clinical Periodontology
    Volume48
    Issue number8
    Early online date4 Apr 2021
    DOIs
    Publication statusE-pub ahead of print - 4 Apr 2021

    Keywords

    • fluorescence
    • periodontal debridement
    • periodontitis
    • photobiomodulation therapy
    • phototherapy
    • randomized controlled trial

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