No Benefit of an Adjunctive Phototherapy Protocol in Treatment of Periodontitis: A split-mouth randomized controlled trial

Philip M. Preshaw; Mark Ide; Susan M. Bissett; Richard Holliday; Nichola Lansdowne; Kimberley Pickering; Judy A. Taylor; Ana M. Levonian; Christine Pleasance; Maria Elena Guarnelli; Anna Simonelli; Chiara Fabbri; Roberto Farina; Fotinos S. Panagakos; Leonardo Trombelli

doi:10.1111/jcpe.13465

No Benefit of an Adjunctive Phototherapy Protocol in Treatment of Periodontitis: A split-mouth randomized controlled trial

Philip M. Preshaw (Lead / Corresponding author)
, Mark Ide
, Susan M. Bissett
, Richard Holliday
, Nichola Lansdowne
, Kimberley Pickering
, Judy A. Taylor
, Ana M. Levonian
, Christine Pleasance
, Maria Elena Guarnelli
, Anna Simonelli
, Chiara Fabbri
, Roberto Farina
, Fotinos S. Panagakos
, Leonardo Trombelli

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

164 Downloads (Pure)

Abstract

Aim: To assess the efficacy of a commercially available adjunctive phototherapy protocol (“Perio-1”) in treatment of periodontitis.

Materials and Methods: In an examiner-blind, randomized, controlled, split-mouth, multicentre study, 60 periodontitis patients received root surface debridement (RSD) in sextants either alone (control sextants) or with the adjunctive phototherapy protocol (test sextants). Re-evaluation was performed at 6, 12 and 24 weeks.

Results: No statistically significant differences in mean (± standard deviation) clinical attachment level (CAL) change from baseline to week 24 were observed between test (−1.00 ± 1.16 mm) and control sextants (−0.87 ± 0.79 mm) at sites with probing pocket depths (PPDs) ≥5 mm (“deep sites”) at baseline (p =.212). Comparisons between test and control sextants for all other parameters (CAL change at all sites, PPD change at deep sites/all sites, bleeding on probing, plaque scores), and for all change intervals, failed to identify any statistically significant differences.

Conclusions: The phototherapy protocol did not provide any additional clinical benefits over those achieved by RSD alone. (German Clinical Trials Register DRKS00011229).

Original language	English
Pages (from-to)	1093-1102
Number of pages	10
Journal	Journal of Clinical Periodontology
Volume	48
Issue number	8
Early online date	4 Apr 2021
DOIs	https://doi.org/10.1111/jcpe.13465
Publication status	Published - Aug 2021

Keywords

fluorescence
periodontal debridement
periodontitis
photobiomodulation therapy
phototherapy
randomized controlled trial

ASJC Scopus subject areas

Periodontics

Access to Document

10.1111/jcpe.13465

Author Accepted ManuscriptAccepted author manuscript, 10.5 MB

Cite this

Preshaw, P. M., Ide, M., Bissett, S. M., Holliday, R., Lansdowne, N., Pickering, K., Taylor, J. A., Levonian, A. M., Pleasance, C., Guarnelli, M. E., Simonelli, A., Fabbri, C., Farina, R., Panagakos, F. S., & Trombelli, L. (2021). No Benefit of an Adjunctive Phototherapy Protocol in Treatment of Periodontitis: A split-mouth randomized controlled trial. Journal of Clinical Periodontology, 48(8), 1093-1102. https://doi.org/10.1111/jcpe.13465

@article{3836486e353846e2a0a84a4e1f366cc5,

title = "No Benefit of an Adjunctive Phototherapy Protocol in Treatment of Periodontitis: A split-mouth randomized controlled trial",

abstract = "Aim: To assess the efficacy of a commercially available adjunctive phototherapy protocol (“Perio-1”) in treatment of periodontitis.Materials and Methods: In an examiner-blind, randomized, controlled, split-mouth, multicentre study, 60 periodontitis patients received root surface debridement (RSD) in sextants either alone (control sextants) or with the adjunctive phototherapy protocol (test sextants). Re-evaluation was performed at 6, 12 and 24 weeks.Results: No statistically significant differences in mean (± standard deviation) clinical attachment level (CAL) change from baseline to week 24 were observed between test (−1.00 ± 1.16 mm) and control sextants (−0.87 ± 0.79 mm) at sites with probing pocket depths (PPDs) ≥5 mm (“deep sites”) at baseline (p =.212). Comparisons between test and control sextants for all other parameters (CAL change at all sites, PPD change at deep sites/all sites, bleeding on probing, plaque scores), and for all change intervals, failed to identify any statistically significant differences.Conclusions: The phototherapy protocol did not provide any additional clinical benefits over those achieved by RSD alone. (German Clinical Trials Register DRKS00011229).",

keywords = "fluorescence, periodontal debridement, periodontitis, photobiomodulation therapy, phototherapy, randomized controlled trial",

author = "Preshaw, \{Philip M.\} and Mark Ide and Bissett, \{Susan M.\} and Richard Holliday and Nichola Lansdowne and Kimberley Pickering and Taylor, \{Judy A.\} and Levonian, \{Ana M.\} and Christine Pleasance and Guarnelli, \{Maria Elena\} and Anna Simonelli and Chiara Fabbri and Roberto Farina and Panagakos, \{Fotinos S.\} and Leonardo Trombelli",

note = "Funding Information: The authors thank all of the patients who participated in this research. Funding for the study was provided by Colgate‐Palmolive (Europe) via research grants to the host institutions of the lead investigators (P.M. Preshaw, M. Ide, L. Trombelli) at the three study centres (Newcastle University, King{\textquoteright}s College London, and University of Ferrara). At the Newcastle centre, the research took place in the Newcastle Dental Clinical Research Facility of the Newcastle University School of Dental Sciences and the Newcastle upon Tyne Hospitals NHS Foundation Trust. Funding Information: P.M. Preshaw has received research funding, honoraria and travel grants from Colgate and from Philips Research. M. Ide has received research funding and honoraria from Colgate and from GlaxoSmithKline. L. Trombelli has received honoraria and travel grants from Colgate. F.S. Panagakos was previously an employee of Colgate‐Palmolive. Publisher Copyright: {\textcopyright} 2021 John Wiley \& Sons A/S. Published by John Wiley \& Sons Ltd",

year = "2021",

month = aug,

doi = "10.1111/jcpe.13465",

language = "English",

volume = "48",

pages = "1093--1102",

journal = "Journal of Clinical Periodontology",

issn = "0303-6979",

publisher = "Blackwell Munksgaard",

number = "8",

}

Preshaw, PM, Ide, M, Bissett, SM, Holliday, R, Lansdowne, N, Pickering, K, Taylor, JA, Levonian, AM, Pleasance, C, Guarnelli, ME, Simonelli, A, Fabbri, C, Farina, R, Panagakos, FS & Trombelli, L 2021, 'No Benefit of an Adjunctive Phototherapy Protocol in Treatment of Periodontitis: A split-mouth randomized controlled trial', Journal of Clinical Periodontology, vol. 48, no. 8, pp. 1093-1102. https://doi.org/10.1111/jcpe.13465

TY - JOUR

T1 - No Benefit of an Adjunctive Phototherapy Protocol in Treatment of Periodontitis

T2 - A split-mouth randomized controlled trial

AU - Preshaw, Philip M.

AU - Ide, Mark

AU - Bissett, Susan M.

AU - Holliday, Richard

AU - Lansdowne, Nichola

AU - Pickering, Kimberley

AU - Taylor, Judy A.

AU - Levonian, Ana M.

AU - Pleasance, Christine

AU - Guarnelli, Maria Elena

AU - Simonelli, Anna

AU - Fabbri, Chiara

AU - Farina, Roberto

AU - Panagakos, Fotinos S.

AU - Trombelli, Leonardo

N1 - Funding Information: The authors thank all of the patients who participated in this research. Funding for the study was provided by Colgate‐Palmolive (Europe) via research grants to the host institutions of the lead investigators (P.M. Preshaw, M. Ide, L. Trombelli) at the three study centres (Newcastle University, King’s College London, and University of Ferrara). At the Newcastle centre, the research took place in the Newcastle Dental Clinical Research Facility of the Newcastle University School of Dental Sciences and the Newcastle upon Tyne Hospitals NHS Foundation Trust. Funding Information: P.M. Preshaw has received research funding, honoraria and travel grants from Colgate and from Philips Research. M. Ide has received research funding and honoraria from Colgate and from GlaxoSmithKline. L. Trombelli has received honoraria and travel grants from Colgate. F.S. Panagakos was previously an employee of Colgate‐Palmolive. Publisher Copyright: © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

PY - 2021/8

Y1 - 2021/8

N2 - Aim: To assess the efficacy of a commercially available adjunctive phototherapy protocol (“Perio-1”) in treatment of periodontitis.Materials and Methods: In an examiner-blind, randomized, controlled, split-mouth, multicentre study, 60 periodontitis patients received root surface debridement (RSD) in sextants either alone (control sextants) or with the adjunctive phototherapy protocol (test sextants). Re-evaluation was performed at 6, 12 and 24 weeks.Results: No statistically significant differences in mean (± standard deviation) clinical attachment level (CAL) change from baseline to week 24 were observed between test (−1.00 ± 1.16 mm) and control sextants (−0.87 ± 0.79 mm) at sites with probing pocket depths (PPDs) ≥5 mm (“deep sites”) at baseline (p =.212). Comparisons between test and control sextants for all other parameters (CAL change at all sites, PPD change at deep sites/all sites, bleeding on probing, plaque scores), and for all change intervals, failed to identify any statistically significant differences.Conclusions: The phototherapy protocol did not provide any additional clinical benefits over those achieved by RSD alone. (German Clinical Trials Register DRKS00011229).

AB - Aim: To assess the efficacy of a commercially available adjunctive phototherapy protocol (“Perio-1”) in treatment of periodontitis.Materials and Methods: In an examiner-blind, randomized, controlled, split-mouth, multicentre study, 60 periodontitis patients received root surface debridement (RSD) in sextants either alone (control sextants) or with the adjunctive phototherapy protocol (test sextants). Re-evaluation was performed at 6, 12 and 24 weeks.Results: No statistically significant differences in mean (± standard deviation) clinical attachment level (CAL) change from baseline to week 24 were observed between test (−1.00 ± 1.16 mm) and control sextants (−0.87 ± 0.79 mm) at sites with probing pocket depths (PPDs) ≥5 mm (“deep sites”) at baseline (p =.212). Comparisons between test and control sextants for all other parameters (CAL change at all sites, PPD change at deep sites/all sites, bleeding on probing, plaque scores), and for all change intervals, failed to identify any statistically significant differences.Conclusions: The phototherapy protocol did not provide any additional clinical benefits over those achieved by RSD alone. (German Clinical Trials Register DRKS00011229).

KW - fluorescence

KW - periodontal debridement

KW - periodontitis

KW - photobiomodulation therapy

KW - phototherapy

KW - randomized controlled trial

UR - https://www.scopus.com/pages/publications/85105965938

U2 - 10.1111/jcpe.13465

DO - 10.1111/jcpe.13465

M3 - Article

C2 - 33817809

SN - 0303-6979

VL - 48

SP - 1093

EP - 1102

JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

IS - 8

ER -

No Benefit of an Adjunctive Phototherapy Protocol in Treatment of Periodontitis: A split-mouth randomized controlled trial

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