Nomenclature for human CYP2D6 alleles

A. K. Daly, J. Brockmöller, F. Broly, M. Eichelbaum, W. E. Evans, F. J. Gonzalez, J. D. Huang, J. R. Idle, M. Ingelman-Sundberg, T. Ishizaki, E. Jacqz-Aigrain, U. A. Meyer, D. W. Nebert, V. M. Steen, C. R. Wolf, U. M. Zanger

    Research output: Contribution to journalArticlepeer-review

    465 Citations (Scopus)


    To standardize CYP2D6 allele nomenclature, and to conform with international human gene nomenclature guidelines, an alternative to the current arbitrary system is described. Based on recommendations for human genome nomenclature, we propose that alleles be designated by CYP2D6 followed by an asterisk and a combination of roman letters and arabic numerals distinct for each allele with the number specifying the key mutation and, where appropriate, a letter specifying additional mutations. Criteria for classification as a separate allele and protein nomenclature are also presented.

    Original languageEnglish
    Pages (from-to)193-200
    Number of pages8
    Issue number3
    Publication statusPublished - 19 Jul 1996


    • Allele nomenclature
    • CYP2D6

    ASJC Scopus subject areas

    • Genetics
    • Pharmacology, Toxicology and Pharmaceutics(all)


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