Non-Contrast MRI Methods as a Tool for the Pre-Operative Assessment and Surveillance of the Arterio-Venous Fistula for Haemodialysis

Conor Macdonald, Stephen Gandy, E C M Avison, Shona Matthew, Rose Ross, John Houston

Research output: Contribution to journalArticle

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Abstract

Objective: To compare non-contrast enhanced MRI with ultrasound (US) for measurement of arm blood vessel geometries and flow velocities in volunteers and patients with end-stage renal disease. Materials and Methods: Subjects were scanned using US (reference standard), and MRI 2D Time of Flight (ToF), 2D Phase Contrast (PC), and 3D multi-echo data image combination (MEDIC). Patients were also scanned after arteriovenous fistula (AVF) surgery. Results: For mean vessel diameters (radial and brachial arteries; cephalic vein) MEDIC measurements were similar to US (p>0.05). However, ToF underestimated the mean diameter of the cephalic vein relative to US (p <0.05). For arterial velocity measurements, the mean values derived by PC-MR and US were similar (p>0.05). Post- operatively the intra-luminal signal intensity was hypo-intense at the anastomosis site using ToF and MEDIC. At the same site the outer boundary of the vessel was consistently lost on ToF, but remained clearly delineated on the MEDIC images. Discussion: With the exception of ToF, the MRI data demonstrated excellent agreement with US for measurements of vessel geometry and flow velocity. Further, the ability to clearly delineate the post-surgery vessel edges with MEDIC MRI suggests that the technique may be useful for surveillance after AVF creation or for patient-specific modelling studies.
Original languageEnglish
Pages (from-to)735-745
Number of pages11
JournalMagnetic Resonance Materials in Physics Biology and Medicine
Volume31
Issue number6
Early online date21 Aug 2018
DOIs
Publication statusPublished - 1 Dec 2018

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Arteriovenous Fistula
Fistula
Renal Dialysis
Veins
Head
Radial Artery
Brachial Artery
Chronic Kidney Failure
Blood Vessels
Volunteers
Patient-Specific Modeling

Keywords

  • MRI
  • Ultrasound
  • Arterio-venous fistula
  • Humans

Cite this

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title = "Non-Contrast MRI Methods as a Tool for the Pre-Operative Assessment and Surveillance of the Arterio-Venous Fistula for Haemodialysis",
abstract = "Objective: To compare non-contrast enhanced MRI with ultrasound (US) for measurement of arm blood vessel geometries and flow velocities in volunteers and patients with end-stage renal disease. Materials and Methods: Subjects were scanned using US (reference standard), and MRI 2D Time of Flight (ToF), 2D Phase Contrast (PC), and 3D multi-echo data image combination (MEDIC). Patients were also scanned after arteriovenous fistula (AVF) surgery. Results: For mean vessel diameters (radial and brachial arteries; cephalic vein) MEDIC measurements were similar to US (p>0.05). However, ToF underestimated the mean diameter of the cephalic vein relative to US (p <0.05). For arterial velocity measurements, the mean values derived by PC-MR and US were similar (p>0.05). Post- operatively the intra-luminal signal intensity was hypo-intense at the anastomosis site using ToF and MEDIC. At the same site the outer boundary of the vessel was consistently lost on ToF, but remained clearly delineated on the MEDIC images. Discussion: With the exception of ToF, the MRI data demonstrated excellent agreement with US for measurements of vessel geometry and flow velocity. Further, the ability to clearly delineate the post-surgery vessel edges with MEDIC MRI suggests that the technique may be useful for surveillance after AVF creation or for patient-specific modelling studies.",
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author = "Conor Macdonald and Stephen Gandy and Avison, {E C M} and Shona Matthew and Rose Ross and John Houston",
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Non-Contrast MRI Methods as a Tool for the Pre-Operative Assessment and Surveillance of the Arterio-Venous Fistula for Haemodialysis. / Macdonald, Conor; Gandy, Stephen; Avison, E C M ; Matthew, Shona; Ross, Rose; Houston, John.

In: Magnetic Resonance Materials in Physics Biology and Medicine, Vol. 31, No. 6, 01.12.2018, p. 735-745.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Non-Contrast MRI Methods as a Tool for the Pre-Operative Assessment and Surveillance of the Arterio-Venous Fistula for Haemodialysis

AU - Macdonald, Conor

AU - Gandy, Stephen

AU - Avison, E C M

AU - Matthew, Shona

AU - Ross, Rose

AU - Houston, John

N1 - European Unions 7th Framework Program for research, technological development and demonstration: 3244487

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Objective: To compare non-contrast enhanced MRI with ultrasound (US) for measurement of arm blood vessel geometries and flow velocities in volunteers and patients with end-stage renal disease. Materials and Methods: Subjects were scanned using US (reference standard), and MRI 2D Time of Flight (ToF), 2D Phase Contrast (PC), and 3D multi-echo data image combination (MEDIC). Patients were also scanned after arteriovenous fistula (AVF) surgery. Results: For mean vessel diameters (radial and brachial arteries; cephalic vein) MEDIC measurements were similar to US (p>0.05). However, ToF underestimated the mean diameter of the cephalic vein relative to US (p <0.05). For arterial velocity measurements, the mean values derived by PC-MR and US were similar (p>0.05). Post- operatively the intra-luminal signal intensity was hypo-intense at the anastomosis site using ToF and MEDIC. At the same site the outer boundary of the vessel was consistently lost on ToF, but remained clearly delineated on the MEDIC images. Discussion: With the exception of ToF, the MRI data demonstrated excellent agreement with US for measurements of vessel geometry and flow velocity. Further, the ability to clearly delineate the post-surgery vessel edges with MEDIC MRI suggests that the technique may be useful for surveillance after AVF creation or for patient-specific modelling studies.

AB - Objective: To compare non-contrast enhanced MRI with ultrasound (US) for measurement of arm blood vessel geometries and flow velocities in volunteers and patients with end-stage renal disease. Materials and Methods: Subjects were scanned using US (reference standard), and MRI 2D Time of Flight (ToF), 2D Phase Contrast (PC), and 3D multi-echo data image combination (MEDIC). Patients were also scanned after arteriovenous fistula (AVF) surgery. Results: For mean vessel diameters (radial and brachial arteries; cephalic vein) MEDIC measurements were similar to US (p>0.05). However, ToF underestimated the mean diameter of the cephalic vein relative to US (p <0.05). For arterial velocity measurements, the mean values derived by PC-MR and US were similar (p>0.05). Post- operatively the intra-luminal signal intensity was hypo-intense at the anastomosis site using ToF and MEDIC. At the same site the outer boundary of the vessel was consistently lost on ToF, but remained clearly delineated on the MEDIC images. Discussion: With the exception of ToF, the MRI data demonstrated excellent agreement with US for measurements of vessel geometry and flow velocity. Further, the ability to clearly delineate the post-surgery vessel edges with MEDIC MRI suggests that the technique may be useful for surveillance after AVF creation or for patient-specific modelling studies.

KW - MRI

KW - Ultrasound

KW - Arterio-venous fistula

KW - Humans

U2 - 10.1007/s10334-018-0700-1

DO - 10.1007/s10334-018-0700-1

M3 - Article

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SP - 735

EP - 745

JO - Magnetic Resonance Materials in Physics Biology and Medicine

JF - Magnetic Resonance Materials in Physics Biology and Medicine

SN - 0968-5243

IS - 6

ER -