Non-local parabolic and hyperbolic models for cell polarisation in heterogeneous cancer cell populations

Vasiliki Bitsouni (Lead / Corresponding author), Raluca Eftimie

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Abstract

Tumours consist of heterogeneous populations of cells. The subpopulations can have different features, including cell motility, proliferation and metastatic potential. The interactions between clonal sub-populations are complex, from stable coexistence to dominant behaviours. The cell-cell interactions, i.e., attraction, repulsion and alignment, processes critical in cancer invasion and metastasis, can be influenced by the mutation of cancer cells. In this study, we develop a mathematical model describing cancer cell invasion and movement for two polarised cancer cell populations with different levels of mutation. We consider a system of non-local hyperbolic equations that incorporate cell-cell interactions in the speed and the turning behaviour of cancer cells, and take a formal parabolic limit to transform this model into a non-local parabolic model. We then investigate the possibility of aggregations to form, and perform numerical simulations for both hyperbolic and parabolic models, comparing the patterns obtained for these models.
Original languageEnglish
Pages (from-to)2600-2632
Number of pages33
JournalBulletin of Mathematical Biology
Volume80
Issue number10
Early online date22 Aug 2018
DOIs
Publication statusPublished - 1 Oct 2018

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Keywords

  • Aggregation patterns
  • Alignment
  • Cancer cells
  • Cell–cell interactions
  • Non-local hyperbolic model
  • Parabolic limit

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