Nontuberculous Mycobacterial Aggregation is Regulated by C:N Balance

W. DePas (Lead / Corresponding author), M. Bergkessel, D. K. Newman

Research output: Contribution to journalConference article

Abstract

The current treatment regimen for nontuberculous mycobacteria (NTM) involves long courses of antibiotic cocktails that demonstrate limited efficacy and cause frequent and serious side effects. Mycobacterium abscessus, in particular, is difficult to treat, motivating studies to identify new therapeutic targets. Experiments using zebrafish and human cell culture lines have demonstrated that M. abscessus is more virulent when aggregated into cord-like biofilms, at least in part because of the decreased ability of phagocytes to efficiently engulf and kill corded M. abscessus cells.
Original languageEnglish
Article number411
Pages (from-to)S310
Number of pages1
JournalPediatric Pulmonology
Volume54
Issue numberS2
Early online date5 Sep 2019
DOIs
Publication statusPublished - Oct 2019

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Nontuberculous Mycobacteria
Zebrafish
Mycobacterium
Phagocytes
Biofilms
Cell Culture Techniques
Anti-Bacterial Agents
Cell Line
Therapeutics

Cite this

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title = "Nontuberculous Mycobacterial Aggregation is Regulated by C:N Balance",
abstract = "The current treatment regimen for nontuberculous mycobacteria (NTM) involves long courses of antibiotic cocktails that demonstrate limited efficacy and cause frequent and serious side effects. Mycobacterium abscessus, in particular, is difficult to treat, motivating studies to identify new therapeutic targets. Experiments using zebrafish and human cell culture lines have demonstrated that M. abscessus is more virulent when aggregated into cord-like biofilms, at least in part because of the decreased ability of phagocytes to efficiently engulf and kill corded M. abscessus cells.",
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Nontuberculous Mycobacterial Aggregation is Regulated by C:N Balance. / DePas, W. (Lead / Corresponding author); Bergkessel, M.; Newman, D. K.

In: Pediatric Pulmonology, Vol. 54, No. S2, 411, 10.2019, p. S310.

Research output: Contribution to journalConference article

TY - JOUR

T1 - Nontuberculous Mycobacterial Aggregation is Regulated by C:N Balance

AU - DePas, W.

AU - Bergkessel, M.

AU - Newman, D. K.

N1 - © 2019 Wiley Periodicals, Inc. First published: 05 September 2019. Supported by the Cystic Fibrosis Foundation and the National Institutes of Health.

PY - 2019/10

Y1 - 2019/10

N2 - The current treatment regimen for nontuberculous mycobacteria (NTM) involves long courses of antibiotic cocktails that demonstrate limited efficacy and cause frequent and serious side effects. Mycobacterium abscessus, in particular, is difficult to treat, motivating studies to identify new therapeutic targets. Experiments using zebrafish and human cell culture lines have demonstrated that M. abscessus is more virulent when aggregated into cord-like biofilms, at least in part because of the decreased ability of phagocytes to efficiently engulf and kill corded M. abscessus cells.

AB - The current treatment regimen for nontuberculous mycobacteria (NTM) involves long courses of antibiotic cocktails that demonstrate limited efficacy and cause frequent and serious side effects. Mycobacterium abscessus, in particular, is difficult to treat, motivating studies to identify new therapeutic targets. Experiments using zebrafish and human cell culture lines have demonstrated that M. abscessus is more virulent when aggregated into cord-like biofilms, at least in part because of the decreased ability of phagocytes to efficiently engulf and kill corded M. abscessus cells.

U2 - 10.1002/ppul.22495

DO - 10.1002/ppul.22495

M3 - Conference article

C2 - 31487429

VL - 54

SP - S310

JO - Pediatric Pulmonology

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