Nontuberculous Mycobacterial Aggregation is Regulated by C:N Balance

W. DePas (Lead / Corresponding author), M. Bergkessel, D. K. Newman

Research output: Contribution to journalConference article

Abstract

The current treatment regimen for nontuberculous mycobacteria (NTM) involves long courses of antibiotic cocktails that demonstrate limited efficacy and cause frequent and serious side effects. Mycobacterium abscessus, in particular, is difficult to treat, motivating studies to identify new therapeutic targets. Experiments using zebrafish and human cell culture lines have demonstrated that M. abscessus is more virulent when aggregated into cord-like biofilms, at least in part because of the decreased ability of phagocytes to efficiently engulf and kill corded M. abscessus cells.
Original languageEnglish
Article number411
Pages (from-to)S310
Number of pages1
JournalPediatric Pulmonology
Volume54
Issue numberS2
Early online date5 Sep 2019
DOIs
Publication statusPublished - Oct 2019

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