Nootropic activity of Moringa oleifera leaves

M. Mohan (Lead / Corresponding author), N. Kaul, A. Punekar, R. Girnar, P. Junnare, L. Patil

Research output: Contribution to journalArticle

14 Citations (Scopus)
4 Downloads (Pure)

Abstract

Objective: To study the nootropic activity of leaves of Moringa oleifera. Methods: Toluene-ethylacetate fraction of methanolic extract of Moringa oleifera (MOE) leaves was assessed for its nootropic activity using passive shock avoidance paradigm and elevated plus maze. MOE ( 50 and 100 mg/kg) was compared with Piracetam (100 mg/kg). Scopolamine (1 mg/kg) was used to induce cognitive dysfunction. The extract was also studied for its effect on gross behaviour. Results: MOE (50 and 100 mg/kg) significantly decreased Transfer Latency(TL) on Day 2. The extract reduced the latency to reach the SFZ and the number of mistakes. No adverse effects were observed upto a dose of 200 mg/kg. Conclusion: Thus the leaves of Moringa oleifera possess a potential for exploring the nootropic principle.
Original languageEnglish
Pages (from-to)59-62
Number of pages4
JournalJournal of Natural Remedies
Volume5
Issue number1
Publication statusPublished - 2005

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Moringa oleifera
Nootropic Agents
Piracetam
Scopolamine Hydrobromide
Toluene
Shock

Keywords

  • Nootropic
  • Moringa oleifera
  • Passive Shock Avoidance
  • Plus Maze

Cite this

Mohan, M., Kaul, N., Punekar, A., Girnar, R., Junnare, P., & Patil, L. (2005). Nootropic activity of Moringa oleifera leaves. Journal of Natural Remedies, 5(1), 59-62.
Mohan, M. ; Kaul, N. ; Punekar, A. ; Girnar, R. ; Junnare, P. ; Patil, L. / Nootropic activity of Moringa oleifera leaves. In: Journal of Natural Remedies. 2005 ; Vol. 5, No. 1. pp. 59-62.
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Mohan, M, Kaul, N, Punekar, A, Girnar, R, Junnare, P & Patil, L 2005, 'Nootropic activity of Moringa oleifera leaves', Journal of Natural Remedies, vol. 5, no. 1, pp. 59-62.

Nootropic activity of Moringa oleifera leaves. / Mohan, M. (Lead / Corresponding author); Kaul, N.; Punekar, A.; Girnar, R.; Junnare, P.; Patil, L.

In: Journal of Natural Remedies, Vol. 5, No. 1, 2005, p. 59-62.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nootropic activity of Moringa oleifera leaves

AU - Mohan, M.

AU - Kaul, N.

AU - Punekar, A.

AU - Girnar, R.

AU - Junnare, P.

AU - Patil, L.

PY - 2005

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AB - Objective: To study the nootropic activity of leaves of Moringa oleifera. Methods: Toluene-ethylacetate fraction of methanolic extract of Moringa oleifera (MOE) leaves was assessed for its nootropic activity using passive shock avoidance paradigm and elevated plus maze. MOE ( 50 and 100 mg/kg) was compared with Piracetam (100 mg/kg). Scopolamine (1 mg/kg) was used to induce cognitive dysfunction. The extract was also studied for its effect on gross behaviour. Results: MOE (50 and 100 mg/kg) significantly decreased Transfer Latency(TL) on Day 2. The extract reduced the latency to reach the SFZ and the number of mistakes. No adverse effects were observed upto a dose of 200 mg/kg. Conclusion: Thus the leaves of Moringa oleifera possess a potential for exploring the nootropic principle.

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Mohan M, Kaul N, Punekar A, Girnar R, Junnare P, Patil L. Nootropic activity of Moringa oleifera leaves. Journal of Natural Remedies. 2005;5(1):59-62.