Nootropic activity of Moringa oleifera leaves

M. Mohan (Lead / Corresponding author), N. Kaul, A. Punekar, R. Girnar, P. Junnare, L. Patil

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)
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Objective: To study the nootropic activity of leaves of Moringa oleifera. Methods: Toluene-ethylacetate fraction of methanolic extract of Moringa oleifera (MOE) leaves was assessed for its nootropic activity using passive shock avoidance paradigm and elevated plus maze. MOE ( 50 and 100 mg/kg) was compared with Piracetam (100 mg/kg). Scopolamine (1 mg/kg) was used to induce cognitive dysfunction. The extract was also studied for its effect on gross behaviour. Results: MOE (50 and 100 mg/kg) significantly decreased Transfer Latency(TL) on Day 2. The extract reduced the latency to reach the SFZ and the number of mistakes. No adverse effects were observed upto a dose of 200 mg/kg. Conclusion: Thus the leaves of Moringa oleifera possess a potential for exploring the nootropic principle.
Original languageEnglish
Pages (from-to)59-62
Number of pages4
JournalJournal of Natural Remedies
Issue number1
Publication statusPublished - 2005


  • Nootropic
  • Moringa oleifera
  • Passive Shock Avoidance
  • Plus Maze


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