Nootropic activity of Moringa oleifera leaves

M. Mohan; N. Kaul; A. Punekar; R. Girnar; P. Junnare; L. Patil

Nootropic activity of Moringa oleifera leaves

M. Mohan (Lead / Corresponding author)
, N. Kaul
, A. Punekar
, R. Girnar
, P. Junnare
, L. Patil

Drug Discovery Unit

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

376 Downloads (Pure)

Abstract

Objective: To study the nootropic activity of leaves of Moringa oleifera. Methods: Toluene-ethylacetate fraction of methanolic extract of Moringa oleifera (MOE) leaves was assessed for its nootropic activity using passive shock avoidance paradigm and elevated plus maze. MOE ( 50 and 100 mg/kg) was compared with Piracetam (100 mg/kg). Scopolamine (1 mg/kg) was used to induce cognitive dysfunction. The extract was also studied for its effect on gross behaviour. Results: MOE (50 and 100 mg/kg) significantly decreased Transfer Latency(TL) on Day 2. The extract reduced the latency to reach the SFZ and the number of mistakes. No adverse effects were observed upto a dose of 200 mg/kg. Conclusion: Thus the leaves of Moringa oleifera possess a potential for exploring the nootropic principle.

Original language	English
Pages (from-to)	59-62
Number of pages	4
Journal	Journal of Natural Remedies
Volume	5
Issue number	1
Publication status	Published - 2005

Keywords

Nootropic
Moringa oleifera
Passive Shock Avoidance
Plus Maze

Access to Document

Nootropic_Moringa_J_Nat_Rem_2005Licence: CC BY

Cite this

@article{130cc6fa42c147d4bfe2f511b7e03516,

title = "Nootropic activity of Moringa oleifera leaves",

abstract = "Objective: To study the nootropic activity of leaves of Moringa oleifera. Methods: Toluene-ethylacetate fraction of methanolic extract of Moringa oleifera (MOE) leaves was assessed for its nootropic activity using passive shock avoidance paradigm and elevated plus maze. MOE ( 50 and 100 mg/kg) was compared with Piracetam (100 mg/kg). Scopolamine (1 mg/kg) was used to induce cognitive dysfunction. The extract was also studied for its effect on gross behaviour. Results: MOE (50 and 100 mg/kg) significantly decreased Transfer Latency(TL) on Day 2. The extract reduced the latency to reach the SFZ and the number of mistakes. No adverse effects were observed upto a dose of 200 mg/kg. Conclusion: Thus the leaves of Moringa oleifera possess a potential for exploring the nootropic principle.",

keywords = "Nootropic, Moringa oleifera, Passive Shock Avoidance, Plus Maze",

author = "M. Mohan and N. Kaul and A. Punekar and R. Girnar and P. Junnare and L. Patil",

year = "2005",

language = "English",

volume = "5",

pages = "59--62",

journal = "Journal of Natural Remedies",

publisher = "Informatics Publishing Limited",

number = "1",

}

TY - JOUR

T1 - Nootropic activity of Moringa oleifera leaves

AU - Mohan, M.

AU - Kaul, N.

AU - Punekar, A.

AU - Girnar, R.

AU - Junnare, P.

AU - Patil, L.

PY - 2005

Y1 - 2005

N2 - Objective: To study the nootropic activity of leaves of Moringa oleifera. Methods: Toluene-ethylacetate fraction of methanolic extract of Moringa oleifera (MOE) leaves was assessed for its nootropic activity using passive shock avoidance paradigm and elevated plus maze. MOE ( 50 and 100 mg/kg) was compared with Piracetam (100 mg/kg). Scopolamine (1 mg/kg) was used to induce cognitive dysfunction. The extract was also studied for its effect on gross behaviour. Results: MOE (50 and 100 mg/kg) significantly decreased Transfer Latency(TL) on Day 2. The extract reduced the latency to reach the SFZ and the number of mistakes. No adverse effects were observed upto a dose of 200 mg/kg. Conclusion: Thus the leaves of Moringa oleifera possess a potential for exploring the nootropic principle.

AB - Objective: To study the nootropic activity of leaves of Moringa oleifera. Methods: Toluene-ethylacetate fraction of methanolic extract of Moringa oleifera (MOE) leaves was assessed for its nootropic activity using passive shock avoidance paradigm and elevated plus maze. MOE ( 50 and 100 mg/kg) was compared with Piracetam (100 mg/kg). Scopolamine (1 mg/kg) was used to induce cognitive dysfunction. The extract was also studied for its effect on gross behaviour. Results: MOE (50 and 100 mg/kg) significantly decreased Transfer Latency(TL) on Day 2. The extract reduced the latency to reach the SFZ and the number of mistakes. No adverse effects were observed upto a dose of 200 mg/kg. Conclusion: Thus the leaves of Moringa oleifera possess a potential for exploring the nootropic principle.

KW - Nootropic

KW - Moringa oleifera

KW - Passive Shock Avoidance

KW - Plus Maze

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-14844345331&origin=inward&txGid=6e0ae0547c53fe7de934e7a7b77d2926

M3 - Article

VL - 5

SP - 59

EP - 62

JO - Journal of Natural Remedies

JF - Journal of Natural Remedies

IS - 1

ER -

Nootropic activity of Moringa oleifera leaves

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this