Normal P300 following extensive damage to the left medial temporal-lobe

M. D. Rugg, C. D. Pickles, D. D. Potter, R. C. Roberts

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    64 Citations (Scopus)

    Abstract

    Event-related potentials (ERPs) were recorded during auditory and visual "oddball" tasks from a patient with a severe verbal memory deficit due to a low grade infiltrating glioma which involved the full extent of the left medial temporal lobe. In both sensory modalities, the patient's oddball-evoked P300s were symmetrical and of normal amplitude. These findings are difficult to reconcile with the hypothesis that the hippocampus, or any other medial temporal structure, makes a substantial contribution to the scalp P300.
    Original languageEnglish
    Pages (from-to)217-222
    Number of pages6
    JournalJournal of Neurology, Neurosurgery & Psychiatry
    Volume54
    Issue number3
    DOIs
    Publication statusPublished - 1991

    Keywords

    • Human hippocampal-formation; endogenous potentials; lobectomy; epilepsy

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