Event-related potentials (ERPs) were recorded during auditory and visual "oddball" tasks from a patient with a severe verbal memory deficit due to a low grade infiltrating glioma which involved the full extent of the left medial temporal lobe. In both sensory modalities, the patient's oddball-evoked P300s were symmetrical and of normal amplitude. These findings are difficult to reconcile with the hypothesis that the hippocampus, or any other medial temporal structure, makes a substantial contribution to the scalp P300.
- Human hippocampal-formation; endogenous potentials; lobectomy; epilepsy
Rugg, M. D., Pickles, C. D., Potter, D. D., & Roberts, R. C. (1991). Normal P300 following extensive damage to the left medial temporal-lobe. Journal of Neurology, Neurosurgery & Psychiatry, 54(3), 217-222. https://doi.org/10.1136/jnnp.54.3.217