Normal P300 following extensive damage to the left medial temporal-lobe

M. D. Rugg; C. D. Pickles; D. D. Potter; R. C. Roberts

doi:10.1136/jnnp.54.3.217

Normal P300 following extensive damage to the left medial temporal-lobe

M. D. Rugg, C. D. Pickles, D. D. Potter, R. C. Roberts

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Abstract

Event-related potentials (ERPs) were recorded during auditory and visual "oddball" tasks from a patient with a severe verbal memory deficit due to a low grade infiltrating glioma which involved the full extent of the left medial temporal lobe. In both sensory modalities, the patient's oddball-evoked P300s were symmetrical and of normal amplitude. These findings are difficult to reconcile with the hypothesis that the hippocampus, or any other medial temporal structure, makes a substantial contribution to the scalp P300.

Original language	English
Pages (from-to)	217-222
Number of pages	6
Journal	Journal of Neurology, Neurosurgery & Psychiatry
Volume	54
Issue number	3
DOIs	https://doi.org/10.1136/jnnp.54.3.217
Publication status	Published - 1991

Keywords

Human hippocampal-formation; endogenous potentials; lobectomy; epilepsy

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10.1136/jnnp.54.3.217

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abstract = "Event-related potentials (ERPs) were recorded during auditory and visual {"}oddball{"} tasks from a patient with a severe verbal memory deficit due to a low grade infiltrating glioma which involved the full extent of the left medial temporal lobe. In both sensory modalities, the patient's oddball-evoked P300s were symmetrical and of normal amplitude. These findings are difficult to reconcile with the hypothesis that the hippocampus, or any other medial temporal structure, makes a substantial contribution to the scalp P300.",

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AU - Rugg, M. D.

AU - Pickles, C. D.

AU - Potter, D. D.

AU - Roberts, R. C.

PY - 1991

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N2 - Event-related potentials (ERPs) were recorded during auditory and visual "oddball" tasks from a patient with a severe verbal memory deficit due to a low grade infiltrating glioma which involved the full extent of the left medial temporal lobe. In both sensory modalities, the patient's oddball-evoked P300s were symmetrical and of normal amplitude. These findings are difficult to reconcile with the hypothesis that the hippocampus, or any other medial temporal structure, makes a substantial contribution to the scalp P300.

AB - Event-related potentials (ERPs) were recorded during auditory and visual "oddball" tasks from a patient with a severe verbal memory deficit due to a low grade infiltrating glioma which involved the full extent of the left medial temporal lobe. In both sensory modalities, the patient's oddball-evoked P300s were symmetrical and of normal amplitude. These findings are difficult to reconcile with the hypothesis that the hippocampus, or any other medial temporal structure, makes a substantial contribution to the scalp P300.

KW - Human hippocampal-formation; endogenous potentials; lobectomy; epilepsy

U2 - 10.1136/jnnp.54.3.217

DO - 10.1136/jnnp.54.3.217

M3 - Article

SN - 0022-3050

VL - 54

SP - 217

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JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

IS - 3

ER -

Normal P300 following extensive damage to the left medial temporal-lobe

Abstract

Keywords

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