Novel actions of leptin in the hippocampus

Jenni Harvey (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    31 Citations (Scopus)

    Abstract

    It is well established that the obese gene product, leptin is an important circulating satiety factor that signals nutritional status to specific hypothalamic nuclei involved in body weight regulation. However, evidence is accumulating that, in addition to its pivotal role as an adiposity signal, leptin is a multi-faceted hormone that plays an important role in a plethora of CNS functions. In this review we summarize the recent advances made in leptin biology, with particular focus on its potential role as a cognitive enhancer and antiepileptic agent in the hippocampus.

    Original languageEnglish
    Pages (from-to)197-206
    Number of pages10
    JournalAnnals of Medicine
    Volume35
    Issue number3
    DOIs
    Publication statusPublished - 9 Jul 2003

    Keywords

    • Epilepsy
    • Hippocampus
    • Leptin
    • Satiety signal
    • Synaptic plasticity

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