Novel biopolymer spray formulation for drug delivery in precision dentistry

Marco Tatullo (Lead / Corresponding author), Benedetta Marrelli, Anastasia Facente, Francesco Paduano, Omar Qutachi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
28 Downloads (Pure)

Abstract

Addressing the growing challenges of periodontal and peri-implant diseases, this study first reports a promising advancement in precision dentistry: an intricately formulated biopolymer spray designed for precise, localized drug delivery during tailored dental procedures. Poly (lactic-co-glycolic acid) (PLGA), recognized for its controlled release, biodegradability, and FDA-approved biocompatibility, forms the core of this formulation. Utilizing the double emulsion method, PLGA microparticles (PLGA-MPs) were loaded with dental antibiotics: sodium amoxicillin (AMX-Na), trihydrate amoxicillin (AMX-Tri), and metronidazole (Met). This antibiotic combination was thoughtfully selected to meet the distinctive requirements of the most impacting dental treatments. The newly developed biopolymer spray underwent thorough in-vitro analysis, revealing an optimized release curve for antibiotics over time, guaranteeing sustained therapeutic efficacy, and dose-dependent efficacy, accommodating personalized treatment approaches. The positive outcomes position the novel biopolymer spray formulation the leaders in advancing localized drug delivery during dental procedures. Moreover, the precise application and the tunable formulation meets the concept of precision medicine: in detail, this formulation represents a significant stride in dental therapeutics, significantly contributing to the predictability of dental implantology.

Original languageEnglish
Article numbere36038
Number of pages10
JournalHeliyon
Volume10
Issue number16
Early online date9 Aug 2024
DOIs
Publication statusPublished - 30 Aug 2024

Keywords

  • Biopolymer spray formulation
  • Dental care
  • Dental therapeutics
  • Drug delivery
  • PLGA microparticles (PLGA-MPs)

ASJC Scopus subject areas

  • General

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