Novel Blockers of the Renin-Angiotensin-Aldosterone System in Chronic Heart Failure

Archyut Valluri, Allan D. Struthers, Chim C Lang (Lead / Corresponding author)

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    3 Citations (Scopus)

    Abstract

    Because of the impressive record of ACE inhibitors in patients with heart failure with reduced ejection fraction, the renin-angiotensin-aldosterone system continues to be pursued as a therapeutic target. Furthermore, the optimal treatment of patients with heart failure with preserved ejection fraction remains unclear. Early trials of direct renin inhibitors suggested that they may have a role, but recent results have not been encouraging. Preliminary trials of angiotensin-receptor/neprilysin inhibitors look positive. Whether these or other drugs will alter current recommendations remains to be seen.
    Original languageEnglish
    JournalCurrent Heart Failure Reports
    DOIs
    Publication statusPublished - Nov 2013

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    Renin-Angiotensin System
    Heart Failure
    Neprilysin
    Angiotensin Receptors
    Angiotensin-Converting Enzyme Inhibitors
    Renin
    Therapeutics
    Pharmaceutical Preparations

    Cite this

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    abstract = "Because of the impressive record of ACE inhibitors in patients with heart failure with reduced ejection fraction, the renin-angiotensin-aldosterone system continues to be pursued as a therapeutic target. Furthermore, the optimal treatment of patients with heart failure with preserved ejection fraction remains unclear. Early trials of direct renin inhibitors suggested that they may have a role, but recent results have not been encouraging. Preliminary trials of angiotensin-receptor/neprilysin inhibitors look positive. Whether these or other drugs will alter current recommendations remains to be seen.",
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