Novel Blockers of the Renin-Angiotensin-Aldosterone System in Chronic Heart Failure

Archyut Valluri; Allan D. Struthers; Chim C Lang

doi:10.1007/s11897-013-0173-5

Novel Blockers of the Renin-Angiotensin-Aldosterone System in Chronic Heart Failure

Archyut Valluri, Allan D. Struthers, Chim C Lang (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Because of the impressive record of ACE inhibitors in patients with heart failure with reduced ejection fraction, the renin-angiotensin-aldosterone system continues to be pursued as a therapeutic target. Furthermore, the optimal treatment of patients with heart failure with preserved ejection fraction remains unclear. Early trials of direct renin inhibitors suggested that they may have a role, but recent results have not been encouraging. Preliminary trials of angiotensin-receptor/neprilysin inhibitors look positive. Whether these or other drugs will alter current recommendations remains to be seen.

Original language	English
Journal	Current Heart Failure Reports
DOIs	https://doi.org/10.1007/s11897-013-0173-5
Publication status	Published - Nov 2013

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10.1007/s11897-013-0173-5

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title = "Novel Blockers of the Renin-Angiotensin-Aldosterone System in Chronic Heart Failure",

abstract = "Because of the impressive record of ACE inhibitors in patients with heart failure with reduced ejection fraction, the renin-angiotensin-aldosterone system continues to be pursued as a therapeutic target. Furthermore, the optimal treatment of patients with heart failure with preserved ejection fraction remains unclear. Early trials of direct renin inhibitors suggested that they may have a role, but recent results have not been encouraging. Preliminary trials of angiotensin-receptor/neprilysin inhibitors look positive. Whether these or other drugs will alter current recommendations remains to be seen.",

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AU - Lang, Chim C

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N2 - Because of the impressive record of ACE inhibitors in patients with heart failure with reduced ejection fraction, the renin-angiotensin-aldosterone system continues to be pursued as a therapeutic target. Furthermore, the optimal treatment of patients with heart failure with preserved ejection fraction remains unclear. Early trials of direct renin inhibitors suggested that they may have a role, but recent results have not been encouraging. Preliminary trials of angiotensin-receptor/neprilysin inhibitors look positive. Whether these or other drugs will alter current recommendations remains to be seen.

AB - Because of the impressive record of ACE inhibitors in patients with heart failure with reduced ejection fraction, the renin-angiotensin-aldosterone system continues to be pursued as a therapeutic target. Furthermore, the optimal treatment of patients with heart failure with preserved ejection fraction remains unclear. Early trials of direct renin inhibitors suggested that they may have a role, but recent results have not been encouraging. Preliminary trials of angiotensin-receptor/neprilysin inhibitors look positive. Whether these or other drugs will alter current recommendations remains to be seen.

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SN - 1546-9530

JO - Current Heart Failure Reports

JF - Current Heart Failure Reports

ER -

Novel Blockers of the Renin-Angiotensin-Aldosterone System in Chronic Heart Failure

Abstract

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