Novel endoscopic multi-firing-clip applicator for endoscopic closure of large colonic perforations

Shuchen Ge, Chengli Song (Lead / Corresponding author), Shiju Yan, Liaoyuan Ai, Jingjing Xu, Mingyang Li, Bing Hu, Alfred Cuschieri

    Research output: Contribution to journalArticle

    3 Citations (Scopus)
    198 Downloads (Pure)

    Abstract

    Background: Existing endoclip closure devices have difficulty in closing large colonic perforation. We developed a novel endoscopic multi-firing-clip applicator (EMFCA) system to address these limitations, and report on its initial evaluation.

    Material and Methods: The functionality and efficacy of the prototype EMFCA equipped with re-openable clamp and preloaded with four clips were assessed using standardized 1.5 cm incisions created in ex-vivo porcine colonic segments. Endoscopic closure of the lacerations with two, three and four clips (n = five for each group) was followed by measurement of the leakage pressure of the three groups. Finite element analysis (FEA) was performed to validate the clip behavior and reliability during deployment.

    Results: All 15 perforations were sealed without leakage until fully distended. The leakage pressures of colonic lacerations sealed with two, three, and four clips were 26.1 ± 2.8 mmHg, 37.3 ± 7.3 mmHg and 42.3 ± 7.4 mmHg, respectively. The mean operation time to deploy one clip was 25.4 ± 5.2 seconds. On FEA, the deformation of the shape of the clip matched that of the intended design, with each clip sustaining a maximum stress of 648.5 MPa without any material failure during deployment.

    Conclusions: These initial results confirm the efficacy of the EMFCA prototype system for endoscopic closure of colonic perforations.

    Original languageEnglish
    Pages (from-to)188-195
    Number of pages8
    JournalMinimally Invasive Therapy and Allied Technologies
    Volume25
    Issue number4
    Early online date24 May 2016
    DOIs
    Publication statusPublished - 2016

    Keywords

    • Gastrointestinal perforation
    • Endoscopic closure
    • Throught-the-scope clips
    • Multi-firing

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