Novel inhibitors of Leishmanial dihydrofolate reductase

Shafinaz F Chowdhury, Raffaella Di Lucrezia, Ramon Hurtado Guerrero, Reto Brun, Jonathan Goodman, Luis M Ruiz-Perez, Dolores Gonzalez Pacanowska, Ian H Gilbert

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    Abstract

    The program DOCK3.5 was used to search the Cambridge Structural Database for novel inhibitors of Leishmanial dihydrofolate reductase. A number of compounds were obtained and screened against the enzyme and against the intact parasite Leishmania donovani and the related organisms Trypanosoma brucei and Trypanosoma cruzi. The compounds screened showed weak activity in both the enzyme assays and the in vitro assays.

    Original languageEnglish
    Pages (from-to)977-980
    Number of pages4
    JournalBioorganic & Medicinal Chemistry Letters
    Volume11
    Issue number8
    DOIs
    Publication statusPublished - 23 Apr 2001

    Cite this

    Chowdhury, S. F., Di Lucrezia, R., Hurtado Guerrero, R., Brun, R., Goodman, J., Ruiz-Perez, L. M., Pacanowska, D. G., & Gilbert, I. H. (2001). Novel inhibitors of Leishmanial dihydrofolate reductase. Bioorganic & Medicinal Chemistry Letters, 11(8), 977-980. https://doi.org/10.1016/S0960-894X(01)00089-0