TY - JOUR
T1 - Novel inhibitors of Leishmanial dihydrofolate reductase
AU - Chowdhury, Shafinaz F
AU - Di Lucrezia, Raffaella
AU - Hurtado Guerrero, Ramon
AU - Brun, Reto
AU - Goodman, Jonathan
AU - Ruiz-Perez, Luis M
AU - Pacanowska, Dolores Gonzalez
AU - Gilbert, Ian H
PY - 2001/4/23
Y1 - 2001/4/23
N2 - The program DOCK3.5 was used to search the Cambridge Structural Database for novel inhibitors of Leishmanial dihydrofolate reductase. A number of compounds were obtained and screened against the enzyme and against the intact parasite Leishmania donovani and the related organisms Trypanosoma brucei and Trypanosoma cruzi. The compounds screened showed weak activity in both the enzyme assays and the in vitro assays.
AB - The program DOCK3.5 was used to search the Cambridge Structural Database for novel inhibitors of Leishmanial dihydrofolate reductase. A number of compounds were obtained and screened against the enzyme and against the intact parasite Leishmania donovani and the related organisms Trypanosoma brucei and Trypanosoma cruzi. The compounds screened showed weak activity in both the enzyme assays and the in vitro assays.
U2 - 10.1016/S0960-894X(01)00089-0
DO - 10.1016/S0960-894X(01)00089-0
M3 - Article
SN - 0960-894X
VL - 11
SP - 977
EP - 980
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
IS - 8
ER -