Novel regulation of cardiac Na pump via phospholemman

Davor Pavlovic, William Fuller, Michael J Shattock

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Abstract

    As the only quantitatively significant Na efflux pathway from cardiac cells, the Na/K ATPase (Na pump) is the primary regulator of intracellular Na. The transmembrane Na gradient it establishes is essential for normal electrical excitability, numerous coupled-transport processes and, as the driving force for Na/Ca exchange, thus seting cardiac Ca load and contractility. As Na influx varies with electrical excitation, heart rate and pathology, the dynamic regulation of Na efflux is essential. It is now widely recognized that phospholemman, a 72 amino acid accessory protein which forms part of the Na pump complex, is the key nexus linking cellular signaling to pump regulation. Phospholemman is the target of a variety of post-translational modifications (including phosphorylation, palmitoylation and glutathionation) and these can dynamically alter the activity of the Na pump. This review summarizes our current understanding of the multiple regulatory.
    Original languageEnglish
    Pages (from-to)83-93
    Number of pages11
    JournalJournal of Molecular and Cellular Cardiology
    Volume61
    DOIs
    Publication statusPublished - Aug 2013

    Fingerprint

    Lipoylation
    Post Translational Protein Processing
    Heart Rate
    Phosphorylation
    Pathology
    Amino Acids
    Proteins
    phospholemman
    sodium-translocating ATPase
    Nexus

    Cite this

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    abstract = "As the only quantitatively significant Na efflux pathway from cardiac cells, the Na/K ATPase (Na pump) is the primary regulator of intracellular Na. The transmembrane Na gradient it establishes is essential for normal electrical excitability, numerous coupled-transport processes and, as the driving force for Na/Ca exchange, thus seting cardiac Ca load and contractility. As Na influx varies with electrical excitation, heart rate and pathology, the dynamic regulation of Na efflux is essential. It is now widely recognized that phospholemman, a 72 amino acid accessory protein which forms part of the Na pump complex, is the key nexus linking cellular signaling to pump regulation. Phospholemman is the target of a variety of post-translational modifications (including phosphorylation, palmitoylation and glutathionation) and these can dynamically alter the activity of the Na pump. This review summarizes our current understanding of the multiple regulatory.",
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    Novel regulation of cardiac Na pump via phospholemman. / Pavlovic, Davor; Fuller, William; Shattock, Michael J.

    In: Journal of Molecular and Cellular Cardiology, Vol. 61, 08.2013, p. 83-93.

    Research output: Contribution to journalArticle

    TY - JOUR

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    AU - Pavlovic, Davor

    AU - Fuller, William

    AU - Shattock, Michael J

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    AB - As the only quantitatively significant Na efflux pathway from cardiac cells, the Na/K ATPase (Na pump) is the primary regulator of intracellular Na. The transmembrane Na gradient it establishes is essential for normal electrical excitability, numerous coupled-transport processes and, as the driving force for Na/Ca exchange, thus seting cardiac Ca load and contractility. As Na influx varies with electrical excitation, heart rate and pathology, the dynamic regulation of Na efflux is essential. It is now widely recognized that phospholemman, a 72 amino acid accessory protein which forms part of the Na pump complex, is the key nexus linking cellular signaling to pump regulation. Phospholemman is the target of a variety of post-translational modifications (including phosphorylation, palmitoylation and glutathionation) and these can dynamically alter the activity of the Na pump. This review summarizes our current understanding of the multiple regulatory.

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