Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters

Beatrice Maria Filippi, Dario R. Alessi

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    Abstract

    A question preoccupying many researchers is how signal transduction pathways control metabolic processes and energy production. A study by Jang et al. ( Jang, C., G. Lee, and J. Chung. 2008. J. Cell Biol. 183: 11 - 17) provides evidence that in Drosophila melanogaster a signaling network controlled by the LKB1 tumor suppressor regulates trafficking of an Sln/dMCT1 monocarboxylate transporter to the plasma membrane. This enables cells to import additional energy sources such as lactate and butyrate, enhancing the repertoire of fuels they can use to power vital activities.

    © 2008 Filippi and Alessi. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the fi rst six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/)

    Original languageEnglish
    Pages (from-to)7-9
    Number of pages3
    JournalJournal of Cell Biology
    Volume183
    Issue number1
    DOIs
    Publication statusPublished - 6 Oct 2008

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