Projects per year
The skin barrier and its endogenous protective mechanisms cope daily with exogenous stressors, of which ultraviolet radiation (UVR) poses an imminent danger. Although the skin is able to reduce the potential damage, there is a need for comprehensive strategies for protection. This is particularly important when developing pharmacological approaches to protect against photocarcinogenesis. Activation of NRF2 has the potential to provide comprehensive and long-lasting protection due to the upregulation of numerous cytoprotective downstream effector proteins that can counteract the damaging effects of UVR. This is also applicable to photodermatosis conditions that exacerbate the damage caused by UVR. This review describes the alterations caused by UVR in normal skin and photosensitive disorders, and provides evidence to support the development of NRF2 activators as pharmacological treatments. Key natural and synthetic activators with photoprotective properties are summarized. Lastly, the gap in knowledge in research associated with photodermatosis conditions is highlighted.
|Number of pages||15|
|Journal||Free Radical Biology and Medicine|
|Early online date||23 Jun 2022|
|Publication status||Published - 1 Aug 2022|
- Pharmacological intervention
FingerprintDive into the research topics of 'NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis'. Together they form a unique fingerprint.
- 2 Finished
A Fully Integrated FLIM-FRET System For Imaging Dynamic Protein - Protein Interactions And Protein Turnover In Single Live Cells And Model Organisms
Appleton, P., Dinkova-Kostova, A., Hiom, K., Januschke, J., MacDonald, M., Saurin, A., Swedlow, J., Tanaka, T. & Weijer, K.
Biotechnology and Biological Sciences Research Council
1/11/20 → 31/03/21