Nrf2 orchestrates fuel partitioning for cell proliferation

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    27 Citations (Scopus)

    Abstract

    Why upregulation of the transcription factor Nrf2 increases tumor cell proliferation is unclear. Mitsuishi et al. (2012) now provide evidence that Nrf2 augments purine nucleotide synthesis, thus supporting tissue hypertrophy. This change in cellular metabolism requires loss of Nrf2 repression by Keap1 as well as costimulation via the PI3K-Akt pathway.
    Original languageEnglish
    Pages (from-to)139-141
    Number of pages3
    JournalCell Metabolism
    Volume16
    Issue number2
    DOIs
    Publication statusPublished - 2012

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