Projects per year
Abstract
Why upregulation of the transcription factor Nrf2 increases tumor cell proliferation is unclear. Mitsuishi et al. (2012) now provide evidence that Nrf2 augments purine nucleotide synthesis, thus supporting tissue hypertrophy. This change in cellular metabolism requires loss of Nrf2 repression by Keap1 as well as costimulation via the PI3K-Akt pathway.
Original language | English |
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Pages (from-to) | 139-141 |
Number of pages | 3 |
Journal | Cell Metabolism |
Volume | 16 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2012 |
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Dive into the research topics of 'Nrf2 orchestrates fuel partitioning for cell proliferation'. Together they form a unique fingerprint.Projects
- 2 Finished
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Application of Selected-Reaction Monitoring (SRM) Mass Spectrometry for the Global Analysis of the Phosphorylation Status of Protein Kinases
Ashford, M. (Investigator), Dillon, J. (Investigator), Hayes, J. (Investigator), McCrimmon, R. (Investigator) & Trost, M. (Investigator)
1/11/12 → 31/03/16
Project: Research
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Pivotal Role of the Keap1-Nrf2 Pathway in the Pathogenesis and Prevention of Non Alcoholic Steatohepatitis Induced Cirrhosis
Ashford, M. (Investigator), Dillon, J. (Investigator), Hayes, J. (Investigator) & McCrimmon, R. (Investigator)
1/11/12 → 31/03/16
Project: Research