TY - JOUR
T1 - Nuclear gene transcription and chromatin in Trypanosoma brucei
AU - Horn, David
N1 - Funding Information:
I would like to thank John Kelly and Martin Taylor for critical reading of the manuscript, Vivian Bellofatto, Dave Barry, Arthur Günzl and Peter Myler for communicating unpublished data and Alexandra K. Ingram for providing sequence data. Preliminary sequence data was obtained from The Insitute for Genomic Research website (www.tigr.org.) and The Sanger Centre website (www.sanger.ac.uk). Research in D.H.'s laboratory is supported by a Research Career Development Fellowship from The Wellcome Trust (052323).
PY - 2001/9
Y1 - 2001/9
N2 - As in other eucaryotes, the nuclear genome in Trypanosoma brucei is organised into silent domains and active domains transcribed by distinct RNA polymerases. The basic mechanisms underlying eucaryotic gene transcription are conserved between humans and yeast, and understood in some detail in these cells. Meanwhile, relatively little is known about the transcription machinery, the chromatin templates or their interactions in trypanosomatids. Here, I discuss and compare nuclear gene transcription in T. brucei with transcription in other eucaryotes focusing in particular on mono-allelic transcription of genes that encode the variant surface glycoproteins.
AB - As in other eucaryotes, the nuclear genome in Trypanosoma brucei is organised into silent domains and active domains transcribed by distinct RNA polymerases. The basic mechanisms underlying eucaryotic gene transcription are conserved between humans and yeast, and understood in some detail in these cells. Meanwhile, relatively little is known about the transcription machinery, the chromatin templates or their interactions in trypanosomatids. Here, I discuss and compare nuclear gene transcription in T. brucei with transcription in other eucaryotes focusing in particular on mono-allelic transcription of genes that encode the variant surface glycoproteins.
KW - Transcription
KW - Trypanosoma brucei
KW - VSG
UR - http://www.scopus.com/inward/record.url?scp=0034892860&partnerID=8YFLogxK
U2 - 10.1016/S0020-7519(01)00264-8
DO - 10.1016/S0020-7519(01)00264-8
M3 - Review article
C2 - 11513885
AN - SCOPUS:0034892860
SN - 0020-7519
VL - 31
SP - 1157
EP - 1165
JO - International Journal for Parasitology
JF - International Journal for Parasitology
IS - 11
ER -