Nuclear gene transcription and chromatin in Trypanosoma brucei

David Horn

doi:10.1016/S0020-7519(01)00264-8

Nuclear gene transcription and chromatin in Trypanosoma brucei

David Horn

Biological Chemistry and Drug Discovery

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

As in other eucaryotes, the nuclear genome in Trypanosoma brucei is organised into silent domains and active domains transcribed by distinct RNA polymerases. The basic mechanisms underlying eucaryotic gene transcription are conserved between humans and yeast, and understood in some detail in these cells. Meanwhile, relatively little is known about the transcription machinery, the chromatin templates or their interactions in trypanosomatids. Here, I discuss and compare nuclear gene transcription in T. brucei with transcription in other eucaryotes focusing in particular on mono-allelic transcription of genes that encode the variant surface glycoproteins.

Original language	English
Pages (from-to)	1157-1165
Number of pages	9
Journal	International Journal for Parasitology
Volume	31
Issue number	11
DOIs	https://doi.org/10.1016/S0020-7519(01)00264-8
Publication status	Published - Sept 2001

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Transcription
Trypanosoma brucei
VSG

ASJC Scopus subject areas

Parasitology
Infectious Diseases

Access to Document

10.1016/S0020-7519(01)00264-8

Cite this

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title = "Nuclear gene transcription and chromatin in Trypanosoma brucei",

abstract = "As in other eucaryotes, the nuclear genome in Trypanosoma brucei is organised into silent domains and active domains transcribed by distinct RNA polymerases. The basic mechanisms underlying eucaryotic gene transcription are conserved between humans and yeast, and understood in some detail in these cells. Meanwhile, relatively little is known about the transcription machinery, the chromatin templates or their interactions in trypanosomatids. Here, I discuss and compare nuclear gene transcription in T. brucei with transcription in other eucaryotes focusing in particular on mono-allelic transcription of genes that encode the variant surface glycoproteins.",

keywords = "Transcription, Trypanosoma brucei, VSG",

author = "David Horn",

note = "Funding Information: I would like to thank John Kelly and Martin Taylor for critical reading of the manuscript, Vivian Bellofatto, Dave Barry, Arthur G{\"u}nzl and Peter Myler for communicating unpublished data and Alexandra K. Ingram for providing sequence data. Preliminary sequence data was obtained from The Insitute for Genomic Research website (www.tigr.org.) and The Sanger Centre website (www.sanger.ac.uk). Research in D.H.'s laboratory is supported by a Research Career Development Fellowship from The Wellcome Trust (052323).",

year = "2001",

month = sep,

doi = "10.1016/S0020-7519(01)00264-8",

language = "English",

volume = "31",

pages = "1157--1165",

journal = "International Journal for Parasitology",

issn = "0020-7519",

publisher = "Elsevier",

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TY - JOUR

T1 - Nuclear gene transcription and chromatin in Trypanosoma brucei

AU - Horn, David

N1 - Funding Information: I would like to thank John Kelly and Martin Taylor for critical reading of the manuscript, Vivian Bellofatto, Dave Barry, Arthur Günzl and Peter Myler for communicating unpublished data and Alexandra K. Ingram for providing sequence data. Preliminary sequence data was obtained from The Insitute for Genomic Research website (www.tigr.org.) and The Sanger Centre website (www.sanger.ac.uk). Research in D.H.'s laboratory is supported by a Research Career Development Fellowship from The Wellcome Trust (052323).

PY - 2001/9

Y1 - 2001/9

N2 - As in other eucaryotes, the nuclear genome in Trypanosoma brucei is organised into silent domains and active domains transcribed by distinct RNA polymerases. The basic mechanisms underlying eucaryotic gene transcription are conserved between humans and yeast, and understood in some detail in these cells. Meanwhile, relatively little is known about the transcription machinery, the chromatin templates or their interactions in trypanosomatids. Here, I discuss and compare nuclear gene transcription in T. brucei with transcription in other eucaryotes focusing in particular on mono-allelic transcription of genes that encode the variant surface glycoproteins.

AB - As in other eucaryotes, the nuclear genome in Trypanosoma brucei is organised into silent domains and active domains transcribed by distinct RNA polymerases. The basic mechanisms underlying eucaryotic gene transcription are conserved between humans and yeast, and understood in some detail in these cells. Meanwhile, relatively little is known about the transcription machinery, the chromatin templates or their interactions in trypanosomatids. Here, I discuss and compare nuclear gene transcription in T. brucei with transcription in other eucaryotes focusing in particular on mono-allelic transcription of genes that encode the variant surface glycoproteins.

KW - Transcription

KW - Trypanosoma brucei

KW - VSG

UR - https://www.scopus.com/pages/publications/0034892860

U2 - 10.1016/S0020-7519(01)00264-8

DO - 10.1016/S0020-7519(01)00264-8

M3 - Review article

C2 - 11513885

AN - SCOPUS:0034892860

SN - 0020-7519

VL - 31

SP - 1157

EP - 1165

JO - International Journal for Parasitology

JF - International Journal for Parasitology

IS - 11

ER -

Nuclear gene transcription and chromatin in Trypanosoma brucei

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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