Nuclear organization and transcriptional dynamics in Dictyostelium

Michelle Stevense, Jonathan R. Chubb, Tetsuya Muramoto

    Research output: Contribution to journalReview articlepeer-review

    20 Citations (Scopus)


    The Dictyostelium model has a set of features uniquely well-suited to developing our understanding of transcriptional control. The complete Dictyostelium discoideum genome sequence has revealed that many of the molecular components regulating transcription in larger eukaryotes are conserved in Dictyostelium, from transcription factors and chromatin components to the enzymes and signals that regulate them. In addition, the system permits visualization of single gene firing events in living cells, which provides a more detailed view of transcription and its relationships to cell and developmental processes. This review will bring together the available knowledge of the structure and dynamics of the Dictyostelium nucleus and discuss recent transcription imaging studies and their implications for stability and accuracy of cell decisions.

    Original languageEnglish
    Pages (from-to)576-586
    Number of pages11
    JournalDevelopment, Growth and Differentiation
    Issue number4
    Publication statusPublished - May 2011


    • Chromatin
    • Live-cell imaging
    • Nuclear organization
    • Stochastic gene expression
    • Transcription
    • Epigenetic memory
    • Mass spectrometry
    • Messenger RNA
    • Cell cycle
    • Real-time
    • Histone-H3 Lysine-4
    • Drosophila embryo
    • DNA methylation
    • Living cells


    Dive into the research topics of 'Nuclear organization and transcriptional dynamics in Dictyostelium'. Together they form a unique fingerprint.

    Cite this