@article{d8f5f7a820e1423eb8b841ad51be738d,
title = "Nucleobase participation in ribozyme catalysis",
abstract = "We constructed a modified form of the VS ribozyme containing an imidazole ring in place of adenine at position 756. The novel ribozyme is active in both cleavage and ligation reactions. The reaction is efficient, although relatively slow. The results are consistent with a role for nucleobase catalysis in the catalytic mechanism of this ribozyme.",
author = "Zheng-yun Zhao and Aileen McLeod and Shinya Harusawa and Lisa Araki and Maho Yamaguchi and Takushi Kurihara and Lilley, {David M. J.}",
note = "dc.publisher: American Chemical Society dc.description.sponsorship: We thank Drs. Tim Wilson and David Norman for discussion. The work was financially supported by Cancer Research-UK and a Grant-in-Aid for High Technology from the Ministry of Education, Science, Sports, and Culture in Japan ",
year = "2005",
doi = "10.1021/ja0502775",
language = "English",
volume = "127",
pages = "5026--5027",
journal = "Journal of the American Chemical Society",
issn = "1520-5126",
publisher = "American Chemical Society",
number = "14",
}