Cells from a human insulin producing tumour have been studied and single channel currents recorded. We have observed three main cation-selective channels in excised patch experiments. An ATP-sensitive potassium channel is present the activity of which can be inhibited by the oral hypoglycaemic drug, tolbutamide. A calcium-activated nonselective cation channel, which is inhibited by AMP could also be seen. In addition a large conductance potassium selective channel, possibly the "maxi" calcium-activated potassium channel is present in these cells.
|Number of pages||4|
|Journal||Pflugers Archiv-European Journal of Physiology|
|Publication status||Published - Sep 1987|
- Adenosine Monophosphate
- Pancreatic Neoplasms
- Ion Channels
- Adenosine Triphosphate