Nucleotide-sensitive ion channels in human insulin producing tumour cells

Nicholas C. Sturgess, Christine A. Carrington, C. Nicholas Hales, Michael L. J. Ashford

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    21 Citations (Scopus)

    Abstract

    Cells from a human insulin producing tumour have been studied and single channel currents recorded. We have observed three main cation-selective channels in excised patch experiments. An ATP-sensitive potassium channel is present the activity of which can be inhibited by the oral hypoglycaemic drug, tolbutamide. A calcium-activated nonselective cation channel, which is inhibited by AMP could also be seen. In addition a large conductance potassium selective channel, possibly the "maxi" calcium-activated potassium channel is present in these cells.
    Original languageEnglish
    Pages (from-to)169-172
    Number of pages4
    JournalPflugers Archiv-European Journal of Physiology
    Volume410
    Issue number1-2
    Publication statusPublished - Sep 1987

    Keywords

    • Adenosine Monophosphate
    • Animals
    • Calcium
    • Humans
    • Pancreatic Neoplasms
    • Ion Channels
    • Potassium
    • Insulin
    • Rats
    • Adult
    • Adenosine Triphosphate
    • Adenoma
    • Female

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