Nucleotide substrate recognition by UDP-N-acetylglucosamine acyltransferase (LpxA) in the first step of lipid A biosynthesis

Keyphrases

• Substrate Recognition 100%
• UDP-GlcNAc 100%
• Lipid A Biosynthesis 100%
• Acyltransferase 100%
• LpxA 100%
• General Base 50%
• Hydroxyl Group 33%
• Acyl Carrier Protein 33%
• Escherichia Coli 16%
• Integral Component 16%
• Lipopolysaccharide 16%
• Lipids 16%
• Side Chain 16%
• Gram-negative Bacteria 16%
• Active Sites 16%
• Acylation 16%
• GlcNAc 16%
• Protein Substrate 16%
• Homotrimer 16%
• Nucleophilic Attack 16%
• Hydrogen Bonds (H-bonds) 16%
• Positively Charged 16%
• Inhibitor Complex 16%
• Nucleophile 16%
• Model Support 16%
• Peptide Inhibitor 16%
• Bacterial Growth 16%
• Substrate Binding Site 16%
• Subunit Interface 16%
• Bacterial Viability 16%
• Base Hydrolysis 16%
• Deprotonated 16%
• Hydrophilic Interaction 16%
• Crystallographic Model 16%
• Catalytic Dyad 16%
• Acyl Donor 16%

Biochemistry, Genetics and Molecular Biology

• Anabolism 100%
• N-Acetylglucosamine 100%
• Uridine Diphosphate 100%
• N-Acetyltransferase 100%
• Lipid A 100%
• Acyl Carrier Protein 28%
• Enzyme 14%
• Crystal Structure 14%
• Binding Site 14%
• Escherichia coli 14%
• Active Site 14%
• Acylation 14%
• Nucleophilicity 14%
• Homotrimer 14%
• Hydrogen Bond 14%
• Gram Negative Bacterium 14%
• Bacterial Viability 14%
• Bacterial Growth 14%
• Lipopolysaccharide 14%