Dynamic soil-structure interaction (DSSI) plays a fundamental role in many geotechnical and/or structural design situations, as clearly shown by the damage which occurred during several recent earthquakes (Kobe 1995; Koaceli 1999; Chi-Chi 1999; L'Aquila 2009). For a long time civil engineering researchers have devoted increasing attention to this subject. Thanks to their efforts, several technical regulations, such as EC8 (2003), have taken DSSI into account. However, many steps are still necessary in order to increase our knowledge regarding this complex phenomenon, as well as to make all the results achieved known to academics and practitioners. This paper presents the results of a shaking table test performed on a scaled physical model consisting of a 3-D steel frame resting on a bed of sand. The experimental results are compared with the numerical ones obtained using a sophisticated elasto-plastic constitutive model recently implemented in the FEM code utilised. The solution of geotechnical problems requires the use of appropriate constitutive models. Many interesting constitutive models have been developed, but only a few of these have been implemented into commercial numerical codes; which is particularly so when dynamic analyses are required. The described experimental results, as well as the comparison between them and the numerical results, allow interesting considerations to be drawn on dynamic soil-structure interaction and on its numerical simulation.