Abstract
Objective: An association between detectable faecal haemoglobin (f-Hb) and both the risk of death from colorectal cancer (CRC) and all-cause mortality has been reported. We set out to confirm or refute this observation in a UK population and to explore the association between f-Hb, as indicated by a positive guaiac faecal occult blood test (gFOBT) result, and different causes of death. Design: All individuals (134 192) who participated in gFOBT screening in Tayside, Scotland between 29/03/2000 and 29/03/2016 were studied by linking their test result (positive or negative) with mortality data from the National Records of Scotland database and following to 30/03/2016. Results: Those with a positive test result (n=2714) had a higher risk of dying than those with a negative result, from CRC: HR 7.79 (95% CI 6.13 to 9.89), p<0.0001, (adjusted for, gender, age, deprivation quintile and medication that can cause bleeding) and all non-CRC causes: HR 1.58 (95% CI 1.45 to 1.73), p<0·0001.· In addition, f-Hb detectable by gFOBT was significantly associated with increased risk of dying from circulatory disease, respiratory disease, digestive diseases (excluding CRC), neuropsychological disease, blood and endocrine disease and non-CRC. Conclusion: The presence of detectable f-Hb is associated with increased risk of death from a wide range of causes.
Original language | English |
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Pages (from-to) | 2116-2123 |
Number of pages | 8 |
Journal | Gut |
Volume | 67 |
Issue number | 12 |
Early online date | 16 Jul 2018 |
DOIs | |
Publication status | Published - Dec 2018 |
Keywords
- all-cause mortality
- colorectal cancer
- faecal haemoglobin
- faecal occult blood
- screening
- bleeding
- Early Detection of Cancer
- Humans
- Middle Aged
- Mortality
- Male
- Cause of Death
- Drug Utilization/statistics & numerical data
- Databases as Topic
- Scotland/epidemiology
- Colorectal Neoplasms/mortality
- Gastrointestinal Hemorrhage/chemically induced
- Female
- Aged
- Occult Blood
- Risk Assessment/methods
- Medical Record Linkage
ASJC Scopus subject areas
- Gastroenterology