Of Mosaicism and Mechanisms: How a JAK1 variant goes awry

Sarah Ross, Doreen Cantrell (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

Abstract

Personalized medicines require understanding the molecular causes of disease. In this issue of Immunity, Gruber et al. identify mosaic expression of a gain-of-function JAK1 genetic mutant that drives multi-organ immune dysregulation via kinase dependent and independent mechanisms. The work highlights how biochemistry can inform therapies to resolve immune disorders.
Original languageEnglish
Pages (from-to)481-484
Number of pages4
JournalImmunity
Volume53
Issue number3
Early online date15 Sep 2020
DOIs
Publication statusPublished - 15 Sep 2020

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