Personalized medicines require understanding the molecular causes of disease. In this issue of Immunity, Gruber et al. reveal that a gain-of-function JAK1 genetic variant results in a mutant protein with mosaic expression that drives multi-organ immune dysregulation via kinase dependent and independent mechanisms. The work highlights how biochemistry can inform therapies to resolve complex immune disorders.
|Number of pages||4|
|Early online date||15 Sept 2020|
|Publication status||Published - Nov 2020|
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases