Okadaic acid: a new probe for the study of cellular regulation

Philip Cohen, Charles F.B. Holmes, Yasumasa Tsukitani

    Research output: Contribution to journalReview article

    1201 Citations (Scopus)

    Abstract

    The tumour promoter okadaic acid is a potent and specific inhibitor of protein phosphatases 1 and 2A. Here we review recent studies which demonstrate that this toxin is extremely useful for identifying biological processes that are controlled through the reversible phosphorylation of proteins.

    Original languageEnglish
    Pages (from-to)98-102
    Number of pages5
    JournalTrends in Biochemical Sciences
    Volume15
    Issue number3
    DOIs
    Publication statusPublished - Mar 1990

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