On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin

Laura Medve, Silvia Achilli, Sonia Serna, Fabio Zuccotto, Norbert Varga, Michel Thépaut, Monica Civera, Corinne Vivès, Franck Fieschi, Niels Reichardt, Anna Bernardi

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Abstract

A library of mannose- and fucose-based glycomimetics was synthesized and screened in a microarray format against a set of C-type lectin receptors (CLRs) that included DC-SIGN, DC-SIGNR, langerin, and dectin-2. Glycomimetic ligands able to interact with dectin-2 were identified for the first time. Comparative analysis of binding profiles allowed their selectivity against other CLRs to be probed.

Original languageEnglish
Pages (from-to)14448-14460
Number of pages13
JournalChemistry - A European Journal
Volume24
Issue number54
Early online date5 Jul 2018
DOIs
Publication statusPublished - 25 Sep 2018

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Keywords

  • C-type lectins
  • carbohydrates
  • drug discovery
  • glycomimetics
  • microarrays

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