@article{cf7c13e99f53453c8f5314621164561f,
title = "On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin",
abstract = "A library of mannose- and fucose-based glycomimetics was synthesized and screened in a microarray format against a set of C-type lectin receptors (CLRs) that included DC-SIGN, DC-SIGNR, langerin, and dectin-2. Glycomimetic ligands able to interact with dectin-2 were identified for the first time. Comparative analysis of binding profiles allowed their selectivity against other CLRs to be probed.",
keywords = "C-type lectins, carbohydrates, drug discovery, glycomimetics, microarrays",
author = "Laura Medve and Silvia Achilli and Sonia Serna and Fabio Zuccotto and Norbert Varga and Michel Th{\'e}paut and Monica Civera and Corinne Viv{\`e}s and Franck Fieschi and Niels Reichardt and Anna Bernardi",
note = "H2020 Marie Sk{\l}odowska-Curie Actions. Grant Number: 642870; Ministero dell'Istruzione, dell'Universit{\`a} e della Ricerca. Grant Number: 2015RNWJAM_002; Ministerio de Econom{\'i}a, Industria y Competitividad, Gobierno de Espa{\~n}a. Grant Number: CTQ2017-90039-R; Agence Nationale de la Recherche. Grant Numbers: ANR- 15-IDEX-02, ANR-10-INSB-05-02, ANR-10-LABX-49-01.",
year = "2018",
month = sep,
day = "25",
doi = "10.1002/chem.201802577",
language = "English",
volume = "24",
pages = "14448--14460",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley",
number = "54",
}