On immunotherapies and cancer vaccination protocols

a mathematical modelling approach

Badal Joshi, Xueying Wang, Sayanti Banerjee, Haiyan Tian, Anastasios Matzavinos, Mark A. J. Chaplain

    Research output: Contribution to journalArticle

    38 Citations (Scopus)

    Abstract

    In this paper we develop a new mathematical model of immunotherapy and cancer vaccination, focusing on the role of antigen presentation and co-stimulatory signaling pathways in cancer immunology. We investigate the effect of different cancer vaccination protocols on the well-documented phenomena of cancer dormancy and recurrence, and we provide a possible explanation of why adoptive (i.e. passive) immunotherapy protocols can sometimes actually promote tumour growth instead of inhibiting it (a phenomenon called immunostimulation), as opposed to active vaccination protocols based on tumour-antigen pulsed dendritic cells. Significantly, the results of our computational simulations suggest that elevated numbers of professional antigen presenting cells correlate well with prolonged time periods of cancer dormancy. (C) 2009 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)820-827
    Number of pages8
    JournalJournal of Theoretical Biology
    Volume259
    Issue number4
    DOIs
    Publication statusPublished - 21 Aug 2009

    Keywords

    • Cancer vaccination
    • Immunotherapy
    • Cancer dormancy
    • Cancer recurrence
    • Cytotoxic T-lymphocytes
    • Immune cells competition
    • Bifurcation analysis
    • Tumor immunology
    • Dendritic cells
    • T cells
    • System
    • Growth
    • Dynamics
    • Perspectives
    • Vaccines

    Cite this

    Joshi, B., Wang, X., Banerjee, S., Tian, H., Matzavinos, A., & Chaplain, M. A. J. (2009). On immunotherapies and cancer vaccination protocols: a mathematical modelling approach. Journal of Theoretical Biology, 259(4), 820-827. https://doi.org/10.1016/j.jtbi.2009.05.001
    Joshi, Badal ; Wang, Xueying ; Banerjee, Sayanti ; Tian, Haiyan ; Matzavinos, Anastasios ; Chaplain, Mark A. J. / On immunotherapies and cancer vaccination protocols : a mathematical modelling approach. In: Journal of Theoretical Biology. 2009 ; Vol. 259, No. 4. pp. 820-827.
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    abstract = "In this paper we develop a new mathematical model of immunotherapy and cancer vaccination, focusing on the role of antigen presentation and co-stimulatory signaling pathways in cancer immunology. We investigate the effect of different cancer vaccination protocols on the well-documented phenomena of cancer dormancy and recurrence, and we provide a possible explanation of why adoptive (i.e. passive) immunotherapy protocols can sometimes actually promote tumour growth instead of inhibiting it (a phenomenon called immunostimulation), as opposed to active vaccination protocols based on tumour-antigen pulsed dendritic cells. Significantly, the results of our computational simulations suggest that elevated numbers of professional antigen presenting cells correlate well with prolonged time periods of cancer dormancy. (C) 2009 Elsevier Ltd. All rights reserved.",
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    Joshi, B, Wang, X, Banerjee, S, Tian, H, Matzavinos, A & Chaplain, MAJ 2009, 'On immunotherapies and cancer vaccination protocols: a mathematical modelling approach', Journal of Theoretical Biology, vol. 259, no. 4, pp. 820-827. https://doi.org/10.1016/j.jtbi.2009.05.001

    On immunotherapies and cancer vaccination protocols : a mathematical modelling approach. / Joshi, Badal; Wang, Xueying; Banerjee, Sayanti; Tian, Haiyan; Matzavinos, Anastasios; Chaplain, Mark A. J.

    In: Journal of Theoretical Biology, Vol. 259, No. 4, 21.08.2009, p. 820-827.

    Research output: Contribution to journalArticle

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    KW - System

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