Abstract
In this paper we develop a new mathematical model of immunotherapy and cancer vaccination, focusing on the role of antigen presentation and co-stimulatory signaling pathways in cancer immunology. We investigate the effect of different cancer vaccination protocols on the well-documented phenomena of cancer dormancy and recurrence, and we provide a possible explanation of why adoptive (i.e. passive) immunotherapy protocols can sometimes actually promote tumour growth instead of inhibiting it (a phenomenon called immunostimulation), as opposed to active vaccination protocols based on tumour-antigen pulsed dendritic cells. Significantly, the results of our computational simulations suggest that elevated numbers of professional antigen presenting cells correlate well with prolonged time periods of cancer dormancy. (C) 2009 Elsevier Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 820-827 |
| Number of pages | 8 |
| Journal | Journal of Theoretical Biology |
| Volume | 259 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 21 Aug 2009 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cancer vaccination
- Immunotherapy
- Cancer dormancy
- Cancer recurrence
- Cytotoxic T-lymphocytes
- Immune cells competition
- Bifurcation analysis
- Tumor immunology
- Dendritic cells
- T cells
- System
- Growth
- Dynamics
- Perspectives
- Vaccines
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