On the synthesis of N-maleoyl amino acids in aqueous media: cautionary tales for the unwary traveller

Michael J. Paterson, Aleksandar Jovanovic

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The high cost or protracted syntheses associated with N-maleoyl amino acid derivatives coupled with a considerable demand from both the life and physical sciences has spurred the search for facile, low-cost routes to these compounds. Herein, we demonstrate that a recently published method purporting to deliver N-maleoyl amino acids by cyclization of maleamic acids in water, instead results in a hydrolysis product, namely the corresponding hemi-maleate salt.

    Original languageEnglish
    Pages (from-to)11-16
    Number of pages6
    JournalARKIVOC
    Publication statusPublished - 2010

    Keywords

    • Maleimides
    • hemi-maleate
    • heterobifunctional crosslinkers
    • cyclization
    • DERIVATIVES
    • MALEIMIDES
    • PEPTIDES
    • ESTER

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