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Abstract
In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.
Original language | English |
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Pages (from-to) | 539-541 |
Number of pages | 3 |
Journal | Cancer Cell |
Volume | 32 |
Issue number | 5 |
Early online date | 13 Nov 2017 |
DOIs | |
Publication status | Published - Nov 2017 |
ASJC Scopus subject areas
- Oncology
- Cell Biology
- Cancer Research
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Dive into the research topics of 'Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival'. Together they form a unique fingerprint.Projects
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