Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

John D. Hayes; Albena T. Dinkova-Kostova

doi:10.1016/j.ccell.2017.10.009

Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

John D. Hayes, Albena T. Dinkova-Kostova (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

228 Downloads (Pure)

Abstract

In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.

Original language	English
Pages (from-to)	539-541
Number of pages	3
Journal	Cancer Cell
Volume	32
Issue number	5
Early online date	13 Nov 2017
DOIs	https://doi.org/10.1016/j.ccell.2017.10.009
Publication status	Published - Nov 2017

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccell.2017.10.009

Author Accepted ManuscriptAccepted author manuscript, 185 KBLicence: CC BY-NC-ND
Author Accepted Manuscript - Figure1Accepted author manuscript, 208 KBLicence: CC BY-NC-ND

Cite this

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title = "Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival",

abstract = "In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.",

author = "Hayes, {John D.} and Dinkova-Kostova, {Albena T.}",

note = "The authors are supported by grant MR/N009851/1 from the Medical Research Council of the UK and grant C20953/A18644 from Cancer Research UK.",

year = "2017",

month = nov,

doi = "10.1016/j.ccell.2017.10.009",

language = "English",

volume = "32",

pages = "539--541",

journal = "Cancer Cell",

issn = "1535-6108",

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T1 - Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

AU - Hayes, John D.

AU - Dinkova-Kostova, Albena T.

N1 - The authors are supported by grant MR/N009851/1 from the Medical Research Council of the UK and grant C20953/A18644 from Cancer Research UK.

PY - 2017/11

Y1 - 2017/11

N2 - In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.

AB - In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.

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U2 - 10.1016/j.ccell.2017.10.009

DO - 10.1016/j.ccell.2017.10.009

M3 - Article

C2 - 29136497

SN - 1535-6108

VL - 32

SP - 539

EP - 541

JO - Cancer Cell

JF - Cancer Cell

IS - 5

ER -

Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

Abstract

ASJC Scopus subject areas

UN SDGs

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The Spatiotemporal Regulation of the Keap1/Nrf2 Pathway (Joint with University College London)

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Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

The Spatiotemporal Regulation of the Keap1/Nrf2 Pathway (Joint with University College London)

Cite this