Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

John D. Hayes, Albena T. Dinkova-Kostova (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    8 Citations (Scopus)
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    Abstract

    In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.

    Original languageEnglish
    Pages (from-to)539-541
    Number of pages3
    JournalCancer Cell
    Volume32
    Issue number5
    Early online date13 Nov 2017
    DOIs
    Publication statusPublished - Nov 2017

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