Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

TY - JOUR

T1 - Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

AU - Hayes, John D.

AU - Dinkova-Kostova, Albena T.

N1 - The authors are supported by grant MR/N009851/1 from the Medical Research Council of the UK and grant C20953/A18644 from Cancer Research UK.

PY - 2017/11

Y1 - 2017/11

N2 - In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.

AB - In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.

UR - https://www.scopus.com/pages/publications/85033721839

U2 - 10.1016/j.ccell.2017.10.009

DO - 10.1016/j.ccell.2017.10.009

M3 - Article

C2 - 29136497

SN - 1535-6108

VL - 32

SP - 539

EP - 541

JO - Cancer Cell

JF - Cancer Cell

IS - 5

ER -