Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

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  Contribution by NRF2 Upregulation to Lung Carcinogenesis and the Possible Therapeutic Value of NRF2 Inhibition by GSK-3 (Joint with Universities of St Andrews, Edinburgh and Pennsylvania)

  Dinkova-Kostova, A. (Investigator), Hayes, J. (Investigator), Henderson, C. (Investigator), Keyse, S. (Investigator), Lamond, A. (Investigator) & Sutherland, C. (Investigator)

  Medical Research Council

  1/05/16 → 31/10/19

  Project: Research

  • NFE2L2 100%
  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 98%
  • Transcription Factor 67%
  • Kelch-like 65%
  • Associated Proteins 65%

• The Spatiotemporal Regulation of the Keap1/Nrf2 Pathway (Joint with University College London)

  Dinkova-Kostova, A. (Investigator)

  Biotechnology and Biological Sciences Research Council

  30/09/14 → 27/02/18

  Project: Research

  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 100%
  • Transcription Factor Nrf2 53%
  • Kelch-like 32%
  • Associated Proteins 32%
  • Kelch-like ECH-associated Protein 1 (Keap1) 29%