Projects per year
Abstract
The discovery, in 2006, that loss-of-function mutations in the filaggrin (FLG) gene are the cause of ichthyosis vulgaris-the most common disorder of keratinization-and also a strong genetic risk factor for atopic eczema, marked a significant breakthrough in the understanding of eczema pathogenesis. Subsequent investigations of the role of FLG-null mutations have identified a series of significant associations with atopic disease phenotypes, including atopic asthma, allergic rhinitis, and peanut allergy. However, many questions remain to be answered in relation to the precise mechanisms by which deficiency of an intracellular protein expressed primarily in the differentiating epidermis may contribute to the development of cutaneous and systemic pathology. This review aims to highlight the key milestones in filaggrin research over the past 25 years, to discuss the mechanistic, clinical, and therapeutic implications, and to consider possible future directions for ongoing investigation.
Original language | English |
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Pages (from-to) | 751-762 |
Number of pages | 12 |
Journal | Journal of Investigative Dermatology |
Volume | 132 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2012 |
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Dive into the research topics of 'One remarkable molecule: filaggrin'. Together they form a unique fingerprint.Projects
- 3 Finished
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Human and Mouse Genetics Studies of Filaggrin-Related Proteins in Eczema and Allergy (Joint with Trinity College Dublin)
Barton, G. (Investigator) & McLean, I. (Investigator)
1/10/10 → 28/02/14
Project: Research
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Aref#d: 22163. The Establishment of a Large Case Collection of Childhood Atopic Dermatitis: A Resource for Gemetoc Research (Joint with Trinity College Dublin)
McLean, I. (Investigator)
1/03/10 → 28/02/14
Project: Research
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Aref#d: 20997. Factors Modulating the Effects of Filaggrin Haploinsufficiency in Ichthyosis Vulgaris and Atopic Eczema (Intermediate Research Fellowship - Dr Sara Brown)
Brown, S. (Investigator), Brown, S. (Investigator), Leigh, I. (Investigator) & McLean, I. (Investigator)
1/07/09 → 30/06/15
Project: Research