One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

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• Finished

  Aref#d: 19815. Wellcome Trust Centre for Drug Discovery (Strategic Award)

  Fairlamb, A. (Investigator), Ferguson, M. (Investigator) & Frearson, J. (Investigator)

  1/01/08 → 31/12/12

  Project: Research

  • Trypanosoma Brucei 100%
  • Enzyme 49%
  • T. Brucei 38%
  • Crystal Structure 30%
  • Drug Discovery 28%

• Aref#d: 19401. Structure, specificity and mechanism of biosynthetic enzymes in trypanosomatids and inhibitor discovery of essential microbial functions (Programme Grant)

  Hunter, B. (Investigator)

  1/11/07 → 31/12/13

  Project: Research

  • Enzyme 100%
  • Crystal Structure 92%
  • Trypanosoma Brucei 69%
  • Active Sites 67%
  • Active Site 61%

• Aref#d: 18185. Characterization and validation of drug targets in the Kinetoplastida (Principal Research Fellowship/Programme Grant)

  Fairlamb, A. (Investigator)

  1/10/06 → 30/09/17

  Project: Research

  • Trypanosoma Brucei 100%
  • Enzyme 43%
  • Trypanothione Reductase 41%
  • African Trypanosomiasis 41%
  • Trypanosoma 41%