'Open minded' cells: how cells can change fate

Silvia Costa, Peter Shaw

    Research output: Contribution to journalArticlepeer-review

    63 Citations (Scopus)


    It has long intrigued researchers why some but not all organisms can regenerate missing body parts. Plants are remarkable in that they can regenerate the entire organism from a small piece of tissue, or even a single cell. Epigenetic mechanisms that control chromatin organization are now known to regulate the cellular plasticity and reprogramming necessary for regeneration. Interestingly, although animals and plants have evolved different strategies and mechanisms to control developmental processes, they have maintained many similarities in the way they regulate chromatin organization. Given that plants can rapidly switch fate, we propose that an understanding of the mechanisms regulating this process in plant cells could provide a new perspective on cellular dedifferentiation in animals.
    Original languageEnglish
    Pages (from-to)101-6
    Number of pages6
    JournalTrends in Cell Biology
    Issue number3
    Publication statusPublished - Mar 2007


    • Animals
    • Arabidopsis
    • Cell Differentiation
    • Cell Division
    • Cell Lineage
    • Cell Nucleus
    • Regeneration


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