Opsoclonus-myoclonus paraneoplastic syndrome in nasopharyngeal carcinoma

Kirsten E. Stewart (Lead / Corresponding author), Martin Zeidler, Devraj Srinivasan, Justin C. L. Yeo

Research output: Contribution to journalArticlepeer-review

Abstract

Nasopharyngeal carcinoma can present with epistaxis, cervical lymphadenopathy, audiological symptoms secondary to eustachian tube dysfunction, pain, or neurological symptoms from tumours directly invading the skull base. It is unusual for patients to present with indirect systemic manifestations. Paraneoplastic neurological syndrome can precede clinically overt malignancy by up to 5 years; therefore, a combination of thorough clinical, laboratory and radiological investigations is required to reach a diagnosis. Intravenous immunoglobulin and steroids might improve neurological symptoms initially and prevent irreversible neuronal damage, but treatment of the underlying cancer is important for long-term resolution. Our case adds to a small but growing body of literature related to anti-Ri antibodies, opsoclonus-myoclonus syndrome presentations, and is the first reported association of this combination with nasopharyngeal carcinoma.

Original languageEnglish
Article numbere250871
Number of pages6
JournalBMJ Case Reports
Volume15
Issue number10
Early online date26 Oct 2022
DOIs
Publication statusPublished - Oct 2022

Keywords

  • Head and neck cancer
  • Immunology
  • Pathology

Fingerprint

Dive into the research topics of 'Opsoclonus-myoclonus paraneoplastic syndrome in nasopharyngeal carcinoma'. Together they form a unique fingerprint.

Cite this