Optical coherence elastography (OCE) as a method for identifying benign and malignant prostate biopsies

Chunhui Li, Guangying Guan, Yuting Ling, Stephen Lang, Ruikang K. Wang, Zhihong Huang, Ghulam Nabi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Objectives. Prostate cancer is the most frequently diagnosed malignancy in men. Digital rectal examination (DRE) - a known clinical tool based on alteration in the mechanical properties of tissues due to cancer has traditionally been used for screening prostate cancer. Essentially, DRE estimates relative stiffness of cancerous and normal prostate tissue. Optical coherence elastography (OCE) are new optical imaging techniques capable of providing cross-sectional imaging of tissue microstructure as well as elastogram in vivo and in real time. In this preliminary study, OCE was used in the setting of the human prostate biopsies ex vivo, and the images acquired were compared with those obtained using standard histopathologic methods. Methods. 120 prostate biopsies were obtained by TRUS guided needle biopsy procedures from 9 patients with clinically suspected cancer of the prostate. The biopsies were approximately 0.8mm in diameter and 12mm in length, and prepared in Formalin solution. Quantitative assessment of biopsy samples using OCE was obtained in kilopascals (kPa) before histopathologic evaluation. The results obtained from OCE and standard histopathologic evaluation were compared provided the cross-validation. Sensitivity, specificity, and positive and negative predictive values were calculated for OCE (histopathology was a reference standard). Results. OCE could provide quantitative elasticity properties of prostate biopsies within benign prostate tissue, prostatic intraepithelial neoplasia, atypical hyperplasia and malignant prostate cancer. Data analysed showed that the sensitivity and specificity of OCE for PCa detection were 1 and 0.91, respectively. PCa had significantly higher stiffness values compared to benign tissues, with a trend of increasing in stiffness with increasing of malignancy. Conclusions. Using OCE, microscopic resolution elastogram is promising in diagnosis of human prostatic diseases. Further studies using this technique to improve the detection and staging of malignant cancer of the prostate are ongoing.

Original languageEnglish
Title of host publicationProceedings Volume 9312
Subtitle of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX
EditorsJames G. Fujimoto, Joseph A. Izatt, Valery V. Tuchin
PublisherSPIE-International Society for Optical Engineering
Number of pages8
Volume9312
ISBN (Electronic)9781628414028
DOIs
Publication statusPublished - 2 Mar 2015
EventSPIE Photonics West 2015: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX - Moscone Center, San Francisco, United States
Duration: 9 Feb 201511 Feb 2015
http://spie.org/x112639.xml

Publication series

Name
ISSN (Electronic)1605-7422

Conference

ConferenceSPIE Photonics West 2015: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX
CountryUnited States
CitySan Francisco
Period9/02/1511/02/15
Internet address

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Keywords

  • Optical coherence elastography (OCE)
  • Prostate biopsy
  • Prostate cancer
  • Young's modulus

Cite this

Li, C., Guan, G., Ling, Y., Lang, S., Wang, R. K., Huang, Z., & Nabi, G. (2015). Optical coherence elastography (OCE) as a method for identifying benign and malignant prostate biopsies. In J. G. Fujimoto, J. A. Izatt, & V. V. Tuchin (Eds.), Proceedings Volume 9312: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX (Vol. 9312). [93122S] SPIE-International Society for Optical Engineering. https://doi.org/10.1117/12.2075711