Optical redox ratio and endogenous porphyrins in the detection of urinary bladder cancer: a patient based biopsy analysis

Scott G. Palmer, Karina Litvinova, Andrey Dunaev, Yubo Ji, David McGloin, Ghulam Nabi (Lead / Corresponding author)

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Abstract

Bladder cancer is among the most common cancers in the UK and conventional detection techniques suffer from low sensitivity, low specificity, or both. Recent attempts to address the disparity have led to progress in the field of autofluorescence as a means to diagnose the disease with high efficiency, however there is still a lot not known about autofluorescence profiles in the disease. The multi-functional diagnostic system “LAKK-M” was used to assess autofluorescence profiles of healthy and cancerous bladder tissue to identify novel biomarkers of the disease. Statistically significant differences were observed in the optical redox ratio (a measure of tissue metabolic activity), the amplitude of endogenous porphyrins and the NADH/porphyrin ratio between tissue types. These findings could advance understanding of bladder cancer and aid in the development of new techniques for detection and surveillance.
Original languageEnglish
Pages (from-to)1062-1073
Number of pages12
JournalJournal of Biophotonics
Volume10
Issue number8
Early online date7 Oct 2016
DOIs
Publication statusPublished - Aug 2017

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Keywords

  • urinary bladder cancer
  • Transitional cell carcinoma
  • multifunctional laser
  • cancer biomarkers
  • detection
  • autoflurorescence

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