Optically enhanced acoustophoresis

Craig McDougall, Paul O'Mahoney, Alan McGuinn, Nicholas A. Willoughby, Yongqiang Qiu, Christine E. M. Démoré, Michael MacDonald

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Regenerative medicine has the capability to revolutionise many aspects of medical care, but for it to make the step from small scale autologous treatments to larger scale allogeneic approaches, robust and scalable label free cell sorting technologies are needed as part of a cell therapy bioprocessing pipeline. In this proceedings we describe several strategies for addressing the requirements for high throughput without labeling via: dimensional scaling, rare species targeting and sorting from a stable state. These three approaches are demonstrated through a combination of optical and ultrasonic forces. By combining mostly conservative and non-conservative forces from two different modalities it is possible to reduce the influence of flow velocity on sorting efficiency, hence increasing robustness and scalability. One such approach can be termed "optically enhanced acoustophoresis" which combines the ability of acoustics to handle large volumes of analyte with the high specificity of optical sorting
Original languageEnglish
Title of host publicationProceedings of SPIE
Subtitle of host publicationOptical Trapping and Optical Micromanipulation XIV
EditorsKishan Dholakia, Gabriel C. Spalding
Place of PublicationUnited States of America
PublisherSPIE-International Society for Optical Engineering
Number of pages10
ISBN (Electronic)9781510611528
ISBN (Print)9781510611511
Publication statusPublished - 25 Aug 2017
EventSPIE NanoScience + Engineering: Optical Trapping and Optical Micromanipulation XIV - San Diego, United States
Duration: 6 Aug 201710 Aug 2017

Publication series

NameProceedings of SPIE
PublisherSPIE - International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1995-756X


ConferenceSPIE NanoScience + Engineering
Country/TerritoryUnited States
CitySan Diego


  • Cell sorting
  • acoustrophoresis
  • optical trapping
  • optical guiding
  • cell therapy
  • bioprocessing


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