Optimal Placement of Origins for DNA Replication

Jens Karschau, J. Julian Blow, Alessandro P. S. de Moura

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    11 Citations (Scopus)

    Abstract

    DNA replication is an essential process in biology and its timing must be robust so that cells can divide properly. Random fluctuations in the formation of replication starting points, called origins, and the subsequent activation of proteins lead to variations in the replication time. We analyze these stochastic properties of DNA and derive the positions of origins corresponding to the minimum replication time. We show that under some conditions the minimization of replication time leads to the grouping of origins, and relate this to experimental data in a number of species showing origin grouping.

    Original languageEnglish
    Article number058101
    Pages (from-to)-
    Number of pages5
    JournalPhysical Review Letters
    Volume108
    Issue number5
    DOIs
    Publication statusPublished - 30 Jan 2012

    Keywords

    • SACCHAROMYCES-CEREVISIAE
    • CHROMOSOME-REPLICATION
    • RECOGNITION COMPLEX
    • YEAST GENOME
    • MODEL
    • CHROMATIN
    • KINETICS
    • REVEALS

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