Optimal stimulation frequency for vibrational optical coherence elastography

Duo Zhang, Jinjiang Wang, Chunhui Li (Lead / Corresponding author), Zhihong Huang

Research output: Contribution to journalArticle

Abstract

Vibrational optical coherence elastography (OCE) is a promising tool for extracting the mechanical property of soft tissue. Purpose of this study is focusing on settling the optimal frequency range for vibrational OCE with evenly distributed stress filed. A finite element model of 2% agar phantom was built by ANSYS with a vibration stimulation frequency range from 200 to 3000 Hz. Practical experiments were carried out for cross-validation with the same frequencies and sample. Lateral and horizontal stress filed distributions under different frequencies were mathematically evaluated by coefficient of variance and degree of linearity. Results from simulation and practical experiment cross-validated each other and 1000 Hz was set as the maximum ideal frequency for vibrational OCE, while the minimum frequency is set by theoretical calculation with a result of 250 Hz. An ex vivo biological sample was utilised to testify performance of vibrational OCE with excitation frequencies in and out of concluded optimal range, which showed that stiffness was better mapped out in optimal frequency range.

Original languageEnglish
Article numbere201960066
Pages (from-to)1-10
Number of pages10
JournalJournal of Biophotonics
Volume13
Issue number2
Early online date11 Oct 2019
DOIs
Publication statusPublished - Feb 2020

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Keywords

  • mechanical property
  • optical coherence elastography
  • optimal frequency
  • vibration elastography

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