Projects per year
Abstract
During the course of a research program aimed at identifying novel antileishmanial compounds, a multi-gram synthesis of N-(trans-4-((4-methoxy-3-((R)-3-methylmorpholino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)cyclohexyl)-2-methylpropane-1-sulfonamide ((R)-1) was required. This letter describes optimisation of the reaction conditions and protecting group strategy for a key Buchwald-Hartwig coupling, delivering the required quantities of (R)-1, as well as further compounds in the series.
Original language | English |
---|---|
Pages (from-to) | 1243-1247 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 60 |
Issue number | 18 |
Early online date | 28 Mar 2019 |
DOIs | |
Publication status | Published - 2 May 2019 |
Keywords
- 2-(Trimethylsilyl)ethoxymethyl (SEM)
- Buchwald-Hartwig coupling
- Protecting group strategy
- Visceral leishmaniasis
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
Fingerprint
Dive into the research topics of 'Optimisation of a Key Cross-Coupling Reaction Towards the Synthesis of a Promising Antileishmanial Compound'. Together they form a unique fingerprint.Projects
- 1 Finished
-
A Translational Engine for Biomedical Discoveries (Strategic Grant)
Fairlamb, A. (Investigator) & Gilbert, I. (Investigator)
1/01/13 → 30/09/15
Project: Research