Optimizing peri-operative care to prevent acute kidney injury

Samira Bell (Lead / Corresponding author), Michelle Lim

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
135 Downloads (Pure)


Post-operative acute kidney injury (AKI) is a common complication of surgery. Rates vary according to type of surgery, ranging from 13% following gastrointestinal surgery and 10% after orthopaedic surgery to 26% following cardiac surgery [1–3].

Understanding the aetiology of post-operative AKI is vital to peri-operative optimization. However, the pathogenesis is complex and usually multifactorial (Figure 1). Renal hypoperfusion plays an important role in post-operative AKI. This can occur as a result of a number of different factors including hypovolaemia, loss of autoregulation during anaesthesia, cardiogenic shock, sepsis and high-risk medicines such as non-steroid anti-inflammatory drugs (NSAIDs) and inhibitors of the renin–angiotensin system.
Original languageEnglish
Pages (from-to)757-759
Number of pages3
JournalNephrology Dialysis Transplantation
Issue number5
Early online date11 Sept 2018
Publication statusPublished - May 2019

ASJC Scopus subject areas

  • Nephrology
  • Transplantation


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