Projects per year
Methods: Three arm, blinded randomized controlled trial in UK ambulatory care. Children with clinical non-severely infected eczema were randomized to receive oral and topical placebos (CTRL), oral antibiotic (flucloxacillin) and topical placebo (OA), or topical fusidic acid and oral placebo (TA), for 1 week. We compared Patient Oriented Eczema Measure (POEM) scores at two weeks using ANCOVA.
Results: 113 children (40 CTRL, 36 OA, 37 TA) were randomized. Mean (SD) baseline POEM scores were, CTRL:13·4(5·1), OA:14·6(5·3) and TA:16·9(5·5). 104 (93%) had one or more of weeping, crusting, pustules or painful skin at baseline. Mean (SD) POEM scores at two-weeks were, CTRL:6·2(6·0), OA:8·3(7·3), and TA:9·3(6·2). Controlling for baseline POEM, OA and TA resulted in a no significant difference in mean (95% confidence interval) POEM scores (1·5 (-1·4 to 4·4) and 1·5 (-1·6 to 4·5) respectively). There were no significant differences in adverse effects and no serious adverse events.
Conclusions: We found rapid resolution in response to topical steroid and emollient treatment, and ruled out a clinically meaningful benefit from the addition of either oral or topical antibiotics. Children seen in ambulatory care with mild clinically infected eczema do not need treatment with antibiotics.
- Anti-bacterial agents
FingerprintDive into the research topics of 'Oral and topical antibiotics for clinically infected eczema in children: a pragmatic randomized controlled trial in ambulatory care'. Together they form a unique fingerprint.
- 1 Finished
The Scottish eHealth Informatics Research Centre (E-HIRCs) (Joint with Universities of Aberdeen, Glasgow, Edinburgh, Strathclyde, St Andrews & Leicester and ISD)
1/03/13 → 31/12/18